6-(4-Aminophenyl)-4-(2-furyl)-2-hydroxynicotinonitrile | 171071-02-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(4-Aminophenyl)-4-(2-furyl)-2-hydroxynicotinonitrile
• 英文别名: 6-(4-aminophenyl)-4-(furan-2-yl)-2-oxo-1H-pyridine-3-carbonitrile
• CAS: 171071-02-6
• 化学式: C₁₆H₁₁N₃O₂
• 分子量: 277.282
• InChiKey: MCWZXFPSWAFDQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-(4-Aminophenyl)-4-(2-furyl)-2-hydroxynicotinonitrile 在 氢氧化钾 、 氨 作用下， 以 甲醇 、 水 、 丙酮 为溶剂， 生成 6-(4-Amino-phenyl)-4-furan-2-yl-2-oxo-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-1,2-dihydro-pyridine-3-carbonitrile
  参考文献：
  名称：

  Synthesis ofN-Glycosylated Pyridines as New Antiviral Agents

  摘要：

  A series of 3-cyanopyridine glycosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. Among the 3-cyanopyridine glycosides 6-(p-methylphenyl) and 6-(p-aminophenyl) were the most selective inhibitors of HIV replication.

  DOI：

  10.1080/15257779508010701
• 作为产物：
  描述：

  ethyl (E)-2-cyano-3-(2-furyl)-2-propenoate 、 4-氨基苯乙酮 在 ammonium acetate 作用下， 以 乙醇 为溶剂， 生成 6-(4-Aminophenyl)-4-(2-furyl)-2-hydroxynicotinonitrile
  参考文献：
  名称：

  Synthesis ofN-Glycosylated Pyridines as New Antiviral Agents

  摘要：

  A series of 3-cyanopyridine glycosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. Among the 3-cyanopyridine glycosides 6-(p-methylphenyl) and 6-(p-aminophenyl) were the most selective inhibitors of HIV replication.

  DOI：

  10.1080/15257779508010701

文献信息

• Synthesis of<i>N</i>-Glycosylated Pyridines as New Antiviral Agents
  作者：E. S. Ibrahim、G. E.H. Elgemeie、M. M. Abbasi、Y. A. Abbas、M. A. Elbadawi、A. M.E. Attia

  DOI：10.1080/15257779508010701

  日期：1995.8

  A series of 3-cyanopyridine glycosides have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV) replication in MT-4 cells. Among the 3-cyanopyridine glycosides 6-(p-methylphenyl) and 6-(p-aminophenyl) were the most selective inhibitors of HIV replication.