2-(2-(hex-1-yn-1-yl)phenyl)benzofuran | 1415462-03-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 2-(2-(hex-1-yn-1-yl)phenyl)benzofuran
• 英文别名: 2-(2-Hex-1-ynylphenyl)-1-benzofuran；2-(2-hex-1-ynylphenyl)-1-benzofuran
• CAS: 1415462-03-1
• 化学式: C₂₀H₁₈O
• 分子量: 274.362
• InChiKey: SUANGMGJQWTLPL-UHFFFAOYSA-N

物化性质

• 沸点：
  427.9±28.0 °C(predicted)
• 密度：
  1.10±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(2-(hex-1-yn-1-yl)phenyl)benzofuran 在 三苯基膦氯金 、 silver trifluoromethanesulfonate 作用下， 以 邻二甲苯 为溶剂， 反应 8.33h， 以99%的产率得到6-butylnaphtho[1,2-b]benzofuran
  参考文献：
  名称：

  Polyaromatic Ribbon/Benzofuran Fusion via Consecutive Endo Cyclizations of Enediynes

  摘要：

  The Sonogashira/5-endo-dig/6-endo-dig cascade fuses a polycyclic aromatic backbone to the electron-rich furan subunit. The transformation proceeds in modest yields as a one-pot reaction. Efficiency of the full cascade is increased by removal of base prior to the addition of gold catalyst. Under these conditions, conversion to the full cascade products is achieved in nearly quantitative yields without purification of the intermediate products. Extension of the cascade toward triynes opens access to benzofuran-fused chrysene derivatives.

  DOI：

  10.1021/ol302922t
• 作为产物：
  描述：

  邻碘溴苯 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 二(氰基苯)二氯化钯 、 三叔丁基膦 、 potassium carbonate 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 邻二甲苯 、 甲苯 为溶剂， 反应 25.33h， 生成 2-(2-(hex-1-yn-1-yl)phenyl)benzofuran
  参考文献：
  名称：

  Polyaromatic Ribbon/Benzofuran Fusion via Consecutive Endo Cyclizations of Enediynes

  摘要：

  The Sonogashira/5-endo-dig/6-endo-dig cascade fuses a polycyclic aromatic backbone to the electron-rich furan subunit. The transformation proceeds in modest yields as a one-pot reaction. Efficiency of the full cascade is increased by removal of base prior to the addition of gold catalyst. Under these conditions, conversion to the full cascade products is achieved in nearly quantitative yields without purification of the intermediate products. Extension of the cascade toward triynes opens access to benzofuran-fused chrysene derivatives.

  DOI：

  10.1021/ol302922t

文献信息

• Polyaromatic Ribbon/Benzofuran Fusion via Consecutive Endo Cyclizations of Enediynes
  作者：Philip M. Byers、Julian I. Rashid、Rana K. Mohamed、Igor V. Alabugin

  DOI：10.1021/ol302922t

  日期：2012.12.7

  The Sonogashira/5-endo-dig/6-endo-dig cascade fuses a polycyclic aromatic backbone to the electron-rich furan subunit. The transformation proceeds in modest yields as a one-pot reaction. Efficiency of the full cascade is increased by removal of base prior to the addition of gold catalyst. Under these conditions, conversion to the full cascade products is achieved in nearly quantitative yields without purification of the intermediate products. Extension of the cascade toward triynes opens access to benzofuran-fused chrysene derivatives.