[Ag(mefenamato)]n | 193674-10-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [Ag(mefenamato)]n
• 英文别名: 2-(2,3-dimethylphenyl)aminobenzoic acid, silver salt；silver 2-[(2,3-dimethylphenyl)amino]benzoate；Silver;2-(2,3-dimethylanilino)benzoate
• CAS: 193674-10-1
• 化学式: Ag*C₁₅H₁₄NO₂
• 分子量: 348.15
• InChiKey: PVQIADOCSNGYSY-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.41
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  52.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [Ag(mefenamato)]n 、 三环己基氯化锡 以 氯仿 为溶剂， 以70%的产率得到Tricyclohexylstannyl 2-(2,3-dimethylanilino)benzoate
  参考文献：
  名称：

  ¹H,¹³C,¹¹⁹Sn NMR,^119mSn Mössbauer, Infrared and Mass Spectrometric Studies of Organotin Carboxylates of 2-(2,3-dimethylphenyl)Aminobenzoic Acid and their Effect on Microorganisms.

  摘要：

  The synthesis of a new series of organotin carboxylates of 2-(2,3-dimethylphenyl)aminobenzoic acid is reported. Multinuclear NMR (H-1, C-13, Sn-119) data have been used as a tool for determining their structures in non-coordinating solvents. Solid state structures have been proposed on the basis of IR and Mossbauer parameters. 2D NMR has been used for the assignments of high-spin systems. Screening tests of these compounds showed that they are highly active against bacteria and fungi.

  DOI：

  10.1080/00945719708000234
• 作为产物：
  描述：

  扑湿痛 、 silver nitrate 在 potassium hydroxide 作用下， 以 水 为溶剂， 生成 [Ag(mefenamato)]n
  参考文献：
  名称：

  New Apoptosis Inducers Containing Anti-inflammatory Drugs and Pnictogen Derivatives: A New Strategy in the Development of Mitochondrial Targeting Chemotherapeutics

  摘要：

  DOI：

  10.1021/acs.jmedchem.2c02126

文献信息

• The anti-breast cancer stem cell properties of gold(<scp>i</scp>)-non-steroidal anti-inflammatory drug complexes
  作者：Alice Johnson、Chibuzor Olelewe、Jong Hyun Kim、Joshua Northcote-Smith、R. Tyler Mertens、Ginevra Passeri、Kuldip Singh、Samuel G. Awuah、Kogularamanan Suntharalingam

  DOI：10.1039/d2sc04707a

  日期：——

  The anti-breast cancer stem cell (CSC) properties of a series of gold(i) complexes comprising various non-steroidal anti-inflammatory drugs (NSAIDs) and triphenylphosphine 1–8 are reported.

  报告了一系列包含各种非甾体抗炎药（NSAIDs）和三苯基膦 1-8 的金（i）复合物的抗乳腺癌干细胞（CSC）特性。
• {2-[(2,3-Dimethylphenyl)amino]benzoato-<i>O</i>:<i>O</i>'}-trimethyltin(IV)
  作者：M. N. Tahir、D. Ülkü、M. Danish、S. Ali、A. Badshah、M. Mazhar

  DOI：10.1107/s0108270196013157

  日期：1997.2.15

  In the title compound, [Sn(C15H14NO2)(CH3)(3)], the Sn atom has a distorted trigonal bipyramidal coordination. The three bonds to methyl groups in the equatorial plane have almost the same values [Sn-C range 2.106 (3)-2.113 (4) Angstrom], but the Sn-O bonds in the axial positions involving one carboxyl O atom [Sn1-O1 2.153 (2) Angstrom] and another symmetry-related carboxyl O atom in the trans position [Sn1-O2 2.495 (2) Angstrom] have quite different values, The O1-Sn1-O2 angle is 173.60 (8)degrees. Each trimethyltin group bridges two neighbouring 2-[(2,3-dimethylphenyl)amino]benzoate ligands via carboxyl moieties to form polymeric chains.