8-Chloro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one | 117811-16-2

• 分子结构分类: 有机化合物 - 碳氢化合物衍生物 - 环庚三烯酮
• 英文名称: 8-Chloro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one
• 英文别名: 8-chloro-11H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11-one；11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one, 8-chloro-；13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-2-one
• CAS: 117811-16-2
• 化学式: C₁₄H₈ClNO
• 分子量: 241.677
• InChiKey: FJSOZRQLIJTERD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  8-Chloro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one 在 三氟甲磺酸 、 硫酸 、 溴 、 silver nitrate 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三乙胺 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 13.83h， 生成 Ethyl 4-<8-Chloro-6-<(ethoxycarbonyl)oxy>-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-ylidene>-1-piperidinecarboxylate
  参考文献：
  名称：

  Hydroxylated metabolites of loratadine: an example of conformational diastereomers due to atropisomerism

  摘要：

  DOI：

  10.1021/jo00297a065
• 作为产物：
  描述：

  8-氯-5,6-二氢-11H-苯并[5,6]环庚烷并[1,2-b]吡啶-11-酮 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 生成 8-Chloro-11H-benzo<5,6>cyclohepta<1,2-b>pyridin-11-one
  参考文献：
  名称：

  Hydroxylated metabolites of loratadine: an example of conformational diastereomers due to atropisomerism

  摘要：

  DOI：

  10.1021/jo00297a065

文献信息

• Tricyclic amide and urea compounds useful for inhibition of G-protein
  申请人：Schering Corporation

  公开号：US05700806A1

  公开（公告）日：1997-12-23

  Novel compounds of Formula (7.0a), (7.0b) or (7.0c): ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a compound of the formula (7.0a), (7.0b) or (7.0c) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being.

  揭示了化合物的新颖结构，其化学式为(7.0a)、(7.0b)或(7.0c)：##STR1##。还揭示了一种抑制Ras功能从而抑制细胞异常生长的方法。该方法包括向生物系统施用化合物的化学式(7.0a)、(7.0b)或(7.0c)。具体而言，该方法抑制了哺乳动物（如人类）中细胞的异常生长。
• Tricyclic amide and urea compounds useful for inhibition of g-protein
  申请人：Schering Corporation

  公开号：US05719148A1

  公开（公告）日：1998-02-17

  A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0: ##STR1## to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of formulas 5.0, 5.1 and 5.2, wherein R is --C(R.sup.20)(R.sup.21)(R.sup.46), and 5.3, 5.3A and 5.3B, wherein R is --N(R.sup.25)(R.sup.48), are disclosed. Also disclosed are processes for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3. Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3.

  抑制Ras功能从而抑制细胞异常生长的方法已被披露。该方法包括向生物系统中施用Formula 1.0的化合物：##STR1##。具体来说，该方法抑制了哺乳动物（如人类）中细胞的异常生长。还披露了Formula 5.0、5.1和5.2的新化合物，其中R为--C(R.sup.20)(R.sup.21)(R.sup.46)，以及Formula 5.3、5.3A和5.3B，其中R为--N(R.sup.25)(R.sup.48)。还披露了制备Formula 5.0、5.1、5.2和5.3的3-取代化合物的方法。此外，还披露了在制备Formula 5.0、5.1、5.2和5.3的3-取代化合物过程中的中间体新化合物。
• Bis-benzo or benzopyrido cyclohepta piperidene, piperidylidene and
  申请人：Schering Corporation

  公开号：US05422351A1

  公开（公告）日：1995-06-06

  Bis-benzo or benzopyrido piperidene, piperidylidene and piperazine compounds of the formula: ##STR1## and pharmaceutically acceptable salts thereof are disclosed, wherein Z represents --(C(R.sup.a).sub.2).sub.m --Y--(C(R.sup.a).sub.2).sub.n -- or ##STR2## The compounds of Formula I possess anti-allergic and anti-inflammatory activity. Methods for preparing and using the compounds are also described.

  本发明揭示了一种具有以下结构的双苯或苯并吡啶哌啶烯，哌啶基亚甲基和哌嗪类化合物的药用盐：其中Z代表--(C(R^a)_2)_m--Y--(C(R^a)_2)_n--或##STR2##。式I的化合物具有抗过敏和抗炎活性。还描述了制备和使用这些化合物的方法。
• Heterocyclic n-oxide derivatives of substituted
  申请人：Schering Corporation

  公开号：US05151423A1

  公开（公告）日：1992-09-29

  Heterocyclic N-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, and pharmaceutically acceptable salts and solvates thereof are disclosed, which possess anti-allergic and anti-inflammatory activity. Methods for preparing and using the compounds are also described.

  本文披露了替代苯并[5,6]环庚七吡啶的杂环N-氧化物衍生物，以及其药用可接受的盐和溶剂化合物，具有抗过敏和抗炎活性。还描述了制备和使用这些化合物的方法。
• Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
  申请人：——

  公开号：US20030055065A1

  公开（公告）日：2003-03-20

  A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0: 1 to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of the formulas 2 are disclosed. Also disclosed are processes for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3. Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3.

  本发明揭示了一种抑制Ras功能，从而抑制细胞异常生长的方法。该方法包括向生物系统中给予1.0:1式化合物。特别是，该方法抑制哺乳动物（如人类）中细胞的异常生长。本发明还揭示了新的2式化合物。还揭示了制备5.0、5.1、5.2和5.3式3-取代化合物的方法。本发明还揭示了制备3-取代化合物5.0、5.1、5.2和5.3式的中间体。