N-脱乙酰基,1,2,3,10-脱甲基秋水仙碱 | 6877-18-5

• 分子结构分类: 有机化合物 - 碳氢化合物衍生物 - 环庚三烯酮
• 中文名称: N-脱乙酰基,1,2,3,10-脱甲基秋水仙碱
• 英文名称: (S)-7-amino-1,2,3,10-tetrahydroxy-6,7-dihydro-5H-benzo[a]heptalen-9-one
• 英文别名: (S)-7-Amino-1,2,3,10-tetrahydroxy-6,7-dihydro-5H-benzo[a]heptalen-9-on；NSC201400；N-Deacetyl-1,2,3-demethylisocolchiceine；(7S)-7-amino-1,2,3,10-tetrahydroxy-6,7-dihydro-5H-benzo[a]heptalen-9-one
• CAS: 6877-18-5
• 化学式: C₁₆H₁₅NO₅
• 分子量: 301.299
• InChiKey: MNJZTCDGAVEFIT-JTQLQIEISA-N

物化性质

• 熔点：
  257-258 °C
• 沸点：
  732.1±60.0 °C(Predicted)
• 密度：
  1.62±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  124
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  原秋水仙碱 在 盐酸 作用下， 生成 N-脱乙酰基,1,2,3,10-脱甲基秋水仙碱
  参考文献：
  名称：

  Blade-Font, Afinidad, 1979, vol. 36, p. 329

  摘要：

  DOI：

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING
  申请人：Smrcka Alan V.

  公开号：US20090221691A1

  公开（公告）日：2009-09-03

  The present invention relates to methods for identifying agents which bind to specific amino acid residues of the protein interaction site of G protein β protein subunit. Compounds identified in accordance with the assay of the invention and methods for using the compound for modulating at least one activity of a G protein are also provide.
• Compositions and Methods for Inhibiting G Protein Signaling
  申请人：University of Rochester

  公开号：US20130116313A1

  公开（公告）日：2013-05-09

  The present invention relates to methods for identifying agents which bind to specific amino acid residues of the protein interaction site of G protein β protein subunit. Compounds identified in accordance with the assay of the invention and methods for using the compound for modulating at least one activity of a G protein are also provided.
• US8748480B2
  申请人：——

  公开号：US8748480B2

  公开（公告）日：2014-06-10
• US8975259B2
  申请人：——

  公开号：US8975259B2

  公开（公告）日：2015-03-10
• [EN] COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'INHIBER LA SIGNALISATION DE LA PROTÉINE G
  申请人：UNIV ROCHESTER

  公开号：WO2009020677A2

  公开（公告）日：2009-02-12

  A method of identifying an agent which binds to at least one amino acid residue of the protein interaction site of G-protein beta subunit composes contacting a G protein beta subunit with a test agent in the presences of a peptide that binds at least one amino acid residue of the protein interaction site of the beta subunit and determining whether the agent inhibits the binding of the peptide.