N-(3-dimethylaminopropyl)-4-chloro-1,8-naphthalimide | 4063-59-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-(3-dimethylaminopropyl)-4-chloro-1,8-naphthalimide
• 英文别名: 6-chloro-2-[3-(dimethylamino)propyl]-1H-benzo[de]isoquinoline-1,3(2H)-dione；6-Chloro-2-[3-(dimethylamino)propyl]benzo[de]isoquinoline-1,3-dione；6-chloro-2-[3-(dimethylamino)propyl]benzo[de]isoquinoline-1,3-dione
• CAS: 4063-59-6
• 化学式: C₁₇H₁₇ClN₂O₂
• 分子量: 316.787
• InChiKey: AFLWTFBOQHTDRO-UHFFFAOYSA-N

物化性质

• 熔点：
  102.0-104.5 °C
• 沸点：
  475.5±30.0 °C(Predicted)
• 密度：
  1.303±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(3-dimethylaminopropyl)-4-chloro-1,8-naphthalimide 在 sodium methylate 、 溶剂黄146 作用下， 生成 N-(3-dimethylaminopropyl)-4-methoxy-1,8-naphthalimide
  参考文献：
  名称：

  Method of controlling scale in aqueous systems

  摘要：

  在工业水系统中抑制水垢的方法包括以下步骤：向工业水系统投加一种水处理聚合物，该聚合物包括至少10摩尔％的羧酸单体和一种苯并二酰亚胺荧光单体，然后监测水系统的荧光。这些聚合物还可用于污水处理中的絮凝和凝聚。

  公开号：

  US11208408B2
• 作为产物：
  描述：

  1,1-二甲基-2-丙基肼 生成 N-(3-dimethylaminopropyl)-4-chloro-1,8-naphthalimide
  参考文献：
  名称：

  Method of controlling scale in aqueous systems

  摘要：

  在工业水系统中抑制水垢的方法包括以下步骤：向工业水系统投加一种水处理聚合物，该聚合物包括至少10摩尔％的羧酸单体和一种苯并二酰亚胺荧光单体，然后监测水系统的荧光。这些聚合物还可用于污水处理中的絮凝和凝聚。

  公开号：

  US11208408B2

文献信息

• Design, synthesis, and biological evaluation of new mitonafide derivatives as potential antitumor drugs
  作者：Ippolito Antonini、Rosaria Volpini、Diego Dal Ben、Catia Lambertucci、Gloria Cristalli

  DOI：10.1016/j.bmc.2008.08.027

  日期：2008.9

  A series of potential DNA-binding antitumor agents, 2-[omega-(alkylamino) alkyl]-6-[omega-(alkylamino) alkyl] amino}-1H-benzo[de] isoquinolin-1,3(2H)-diones and 1,7-bis6-[(omega-(dimethylamino) alkyl) amino]-1,3dioxo-1H-benzo[de] isoquinolin-2(3H)-yl}-4-methyl-4-azaheptanes, have been prepared as mitonafide derivatives. Their DNA-binding ability and cytotoxic activity have been evaluated. Some of the target compounds have shown high DNA affinity as well as relevant cytotoxic properties. (C) 2008 Elsevier Ltd. All rights reserved.
• Fluorescence Signalling of Transition Metal Ions by Multi-Component Systems Comprising 4-Chloro-1,8-naphthalimide as Fluorophore
  作者：B. Ramachandram、N.B. Sankaran、R. Karmakar、S. Saha、A. Samanta

  DOI：10.1016/s0040-4020(00)00527-5

  日期：2000.9

  Fluorescence of 1a and 1b is 'switched on' by the quenching transition metal ions and the extent of fluorescence enhancement is found to be considerably higher than that expected on the basis of photoinduced intramolecular electron transfer in the systems. The observation has been rationalised taking into account the hydrated nature of the transition metal salts and preferential solvation of the fluorophore by the water molecules. (C) 2000 Elsevier Science Ltd. All rights reserved.
• Path-selective photoinduced electron transfer (PET) in a membrane-associated system studied by pH-dependent fluorescence
  作者：Jialong Liu、A. Prasanna de Silva

  DOI：10.1016/j.ica.2011.09.059

  日期：2012.2

  The pH-dependent fluorescence behavior of two regioisomeric 'receptor(1)-spacer(1)-fluorophore-spacer(2)-receptor(2)' systems 1 and 2 in micellar solutions of sodium dodecyl sulfate show that photoinduced electron transfer (PET) only occurs from the amine group connected to the 4-amino position of the aminonaphthalimide fluorophore in both cases. This demonstrates the directing influence of the photogenerated electric field within the aminonaphthalimide excited state on the electron transfer process. Since path-selectivity of PET is also known within the membrane-bound photosynthetic reaction center in bacteria, its origins may be illuminated by the simple experiments described here. (C) 2011 Elsevier B. V. All rights reserved.
• METHOD OF CONTROLLING SCALE IN AQUEOUS SYSTEMS
  申请人：Nouryon Chemicals International B.V.

  公开号：EP3977104A1

  公开（公告）日：2022-04-06
• METHOD OF CONTROLLING CARBONATE SCALE IN AQUEOUS SYSTEMS
  申请人：RODRIGUES Klin Aloysius

  公开号：US20220227648A1

  公开（公告）日：2022-07-21

  A method of inhibiting carbonate scale in an industrial water system includes the steps of dosing the industrial water system with a water treatment polymer comprising at least 60 mol % of carboxylic acid monomer and a quaternized naphthalimide fluorescent monomer as disclosed herein, and then monitoring the fluorescence of the water system. If both maleic acid and phosphino moieties are included in the water treatment polymer, then the maleic acid is present as no greater than 70 mol % of the water treatment polymer. If the polymer contains a sulfonic acid monomer, the polymer is a fluorescence efficient polymer.