| 1427703-09-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• CAS: 1427703-09-0
• 化学式: C₅₀H₄₈N₁₀NiO₂S₄
• 分子量: 1007.95
• InChiKey: RKVKACZPNDOCCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  sodium isocyanate 、 nickel(II) acetate tetrahydrate 、 2-(pyridin-3-ylmethylsulfanyl)phenylamine 以 甲醇 、 水 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  Nickel(II) complexes with 2-(pyridin-3-ylmethylsulfanyl)phenylamine and halide/pseudohalides: Synthesis, structural characterisation, interaction with CT-DNA and bovine serum albumin, and antibacterial activity

  摘要：

  A new series of hexacoordinated octahedral nickel(II) complexes of 2-(pyridin-3-ylmethylsulfanyl)phenylamine (L) formulated as [Ni(L)(4)(X)(2)] (1-4) [where X = Cl- (1); NCO- (2); N-3(-) (3) and NCS- (4)] has been synthesised and characterised by physicochemical, spectroscopic tools. Details of structural study of complex 1 using single crystal X-ray crystallography showed that distorted tetragonal environment around nickel(II) ion has been satisfied by four pyridinic-N donors of four organic moieties (L) and two chloride ions. All the complexes are redox active and the electrochemical study of the complexes showed only cathodic Ni-II/Ni-I redox couples in the range of -0.61 to -695 V versus Ag/AgCl. Interactions of 1 towards calf thymus-DNA by spectroscopic, viscosity-measurement and electrochemical study and towards bovine serum albumin (BSA) with the help of absorption and fluorescence spectroscopy were examined. Antibacterial activity of the complexes (1-4) studied by agar disc diffusion method showed the comparable inhibition activity of the nickel(II) complexes against some pathogenic bacteria namely Escherichia coli, Vibrio cholerae, Streptococcus pneumonia, Shigella sp. and Bacillus cereus. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.12.031