(4-{4-[(R)-amino(4-fluorophenyl)-methyl]piperidin-1-ylsulphonyl}phenyl)[4-(4-(trifluoromethoxy)phenyl)pyrimidin-2-yl]amine | 1049105-24-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (4-{4-[(R)-amino(4-fluorophenyl)-methyl]piperidin-1-ylsulphonyl}phenyl)[4-(4-(trifluoromethoxy)phenyl)pyrimidin-2-yl]amine
• 英文别名: N-[4-[4-[(R)-amino-(4-fluorophenyl)methyl]piperidin-1-yl]sulfonylphenyl]-4-[4-(trifluoromethoxy)phenyl]pyrimidin-2-amine
• CAS: 1049105-24-9
• 化学式: C₂₉H₂₇F₄N₅O₃S
• 分子量: 601.625
• InChiKey: YOGCGONDXWREPX-MHZLTWQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  12

文献信息

• NOVEL PHENYL(4-PHENYLPYRIMIDIN-2-YL)AMINE DERIVATIVES, THEIR PREPARATION, AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS IKK INHIBITORS
  申请人：BOUABOULA Monsif

  公开号：US20100069417A1

  公开（公告）日：2010-03-18

  The disclosure relates to a compound of formula (I): wherein R, R2, R3, R4, R5, Z, W and D are as defined in the specification, to compositions containing them, to processes for preparing them, and to their use in the treatment or prevention of conditions capable of being modulated by the inhibition of the activity of protein kinases.

  本公开涉及一种式(I)的化合物：其中R、R2、R3、R4、R5、Z、W和D的定义如规范中所述，以及包含它们的组合物、制备它们的过程，以及它们在治疗或预防能够通过抑制蛋白激酶活性而调节的疾病中的应用。