1-(7-Oxabicyclo[4.1.0]heptan-1-yl)propan-2-ol | 609848-80-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• 英文名称: 1-(7-Oxabicyclo[4.1.0]heptan-1-yl)propan-2-ol
• 英文别名: 1-(7-oxabicyclo[4.1.0]heptan-1-yl)propan-2-ol
• CAS: 609848-80-8
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: GQUBFANGBNHUAP-UHFFFAOYSA-N

物化性质

• 沸点：
  252.7±8.0 °C(Predicted)
• 密度：
  1.092±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(7-Oxabicyclo[4.1.0]heptan-1-yl)propan-2-ol 在 三乙基铝 作用下， 以 四氢呋喃 为溶剂， 以89%的产率得到2-亚甲基环己烷-1-醇
  参考文献：
  名称：

  AlEt3-promoted eliminative ring-opening of β-hydroxy epoxides: highly stereoselective synthesis of terminal α-hydroxy olefins

  摘要：

  AlEt3-promoted eliminative ring-opening of beta-epoxy alcohols leading to alpha-hydroxy olefins is reported. This eliminative ring-opening reaction is shown to be highly stereoselective, thus providing an alternative asymmetric synthesis for a-hydroxy olefins. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(03)00457-9
• 作为产物：
  描述：

  1-(cyclohex-1-en-1-yl)propan-2-ol 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 生成 1-(7-Oxabicyclo[4.1.0]heptan-1-yl)propan-2-ol
  参考文献：
  名称：

  AlEt3-promoted eliminative ring-opening of β-hydroxy epoxides: highly stereoselective synthesis of terminal α-hydroxy olefins

  摘要：

  AlEt3-promoted eliminative ring-opening of beta-epoxy alcohols leading to alpha-hydroxy olefins is reported. This eliminative ring-opening reaction is shown to be highly stereoselective, thus providing an alternative asymmetric synthesis for a-hydroxy olefins. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(03)00457-9

文献信息

• AlEt3-promoted eliminative ring-opening of β-hydroxy epoxides: highly stereoselective synthesis of terminal α-hydroxy olefins
  作者：Fei Wang、Shao Hua Wang、Yong Qiang Tu、Shi Kuo Ren

  DOI：10.1016/s0957-4166(03)00457-9

  日期：2003.8

  AlEt3-promoted eliminative ring-opening of beta-epoxy alcohols leading to alpha-hydroxy olefins is reported. This eliminative ring-opening reaction is shown to be highly stereoselective, thus providing an alternative asymmetric synthesis for a-hydroxy olefins. (C) 2003 Elsevier Ltd. All rights reserved.