(S)-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid 1,7-diphenyl-4-heptylamide | 262843-18-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (S)-1,2,3,4-tetrahydro-3-isoquinoline carboxylic acid 1,7-diphenyl-4-heptylamide
• 英文别名: (3S)-N-(1,7-diphenylheptan-4-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
• CAS: 262843-18-5
• 化学式: C₂₉H₃₄N₂O
• 分子量: 426.602
• InChiKey: SVYKYHUWKKAVEG-NDEPHWFRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Heterocyclic 2-substituted ketoamides
  申请人：——

  公开号：US20010012895A1

  公开（公告）日：2001-08-09

  The present disclosure describes novel compounds and compositions which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The present compounds and compositions may also be useful against a variety of disorders including, for example, multi-drug resistance, human immunodeficiency virus (HIV), cardiac injury, and neurological disorders, and may be useful for controlling parasites and invoking immunosuppression.

  本公开内容描述了特别适用于治疗哺乳动物脱发的新型化合物和组合物，包括阻止和/或逆转脱发以及促进毛发生长。本发明的化合物和组合物还可用于防治多种疾病，例如多重耐药性、人类免疫缺陷病毒（HIV）、心脏损伤和神经系统疾病，并可用于控制寄生虫和诱发免疫抑制。
• HETEROCYCLIC 2-SUBSTITUTED KETOAMIDES USEFUL FOR TREATING HAIR LOSS IN MAMMALS
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP1117640A1

  公开（公告）日：2001-07-25
• US6300341B1
  申请人：——

  公开号：US6300341B1

  公开（公告）日：2001-10-09
• US6307049B1
  申请人：——

  公开号：US6307049B1

  公开（公告）日：2001-10-23
• [EN] HETEROCYCLIC 2-SUBSTITUTED KETOAMIDES USEFUL FOR TREATING HAIR LOSS IN MAMMALS<br/>[FR] CETOAMIDES HETEROCYCLIQUES 2-SUBSTITUES DESTINEES AU TRAITEMENT DE LA CHUTE DE CHEVEUX CHEZ LES MAMMIFERES
  申请人：PROCTER & GAMBLE

  公开号：WO2000018733A1

  公开（公告）日：2000-04-06

  The present disclosure describes novel compounds (formula (I)), wherein W is selected from nil, hydrogen, and lower alkyl; A is selected from nil and alkyl; X and Y are each, independently, selected from C(O), P(O), N, O and S, wherein: (i) when X is C(O) then R3 is nil and Y is selected from N, O, and S, (ii) when X is P(O) then R3 is nil and Y is selected from the group consisting of N and O; (iii) when X is N then R3 is selected from hydrogen, alkyl, and arylalkyl, Y is C(O), and R2 is nil; (iv) when X is O then R3 is nil, Y is C(O), and R2 is nil; and (v) when X is S then R3 is nil, Y is C(O), and R2 is nil; and wherein the substitutents R1 to R10 are defined herein, and compositions which are particularly useful for treating hair loss in mammals, including arresting and/or reversing hair loss and promoting hair growth. The present compounds and compositions may also be useful against a variety of disorders including, for example, multi-drug resistance, human immunodeficiency virus (HIV), cardiac injury, and neurological disorders, and may be useful for controlling parasites and invoking immunosuppression.