(S)-(8-(6-chloro-5-fluoro-1H-benzo[d]imidazol-2-yl)-4-(5-methoxypyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)methanol | 1334176-40-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: (S)-(8-(6-chloro-5-fluoro-1H-benzo[d]imidazol-2-yl)-4-(5-methoxypyridin-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)methanol
• 英文别名: [(3S)-8-(5-chloro-6-fluoro-1H-benzimidazol-2-yl)-4-(5-methoxypyridin-2-yl)-2,3-dihydro-1,4-benzoxazin-3-yl]methanol
• CAS: 1334176-40-7
• 化学式: C₂₂H₁₈ClFN₄O₃
• 分子量: 440.861
• InChiKey: KALRQYKXWDYSRI-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  83.5
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF
  申请人：Daewoong Pharmaceutical Co., Ltd

  公开号：EP2627652B1

  公开（公告）日：2015-12-16
• NOVEL PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF
  申请人：Daewoong Pharmaceutical Co., Ltd

  公开号：EP2627652A2

  公开（公告）日：2013-08-21
• US8026235B1
  申请人：——

  公开号：US8026235B1

  公开（公告）日：2011-09-27
• [EN] NOVEL PYRIDYL BENZOXAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USE THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRIDYL-BENZOXAZINE, COMPOSITION PHARMACEUTIQUE LES CONTENANT ET LEUR UTILISATION
  申请人：DAE WOONG PHARMA

  公开号：WO2012050380A2

  公开（公告）日：2012-04-19

  Discloses is a benzoxazine benzimidazole derivative, represented by Chemical Formula 1, functioning as an antagonist to the vanilloid receptor-1, a pharmaceutical composition comprising the same, and the use thereof. The benzoxazine benzimidazole derivative can be useful for preventing or treating a disease associated with antagonistic activity of vanilloid receptor-1, without hyperthermia.