(E)-3-(3-(2,6-dimethylstyryl)phenyl)-N-methylpropanamide | 1075176-11-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: (E)-3-(3-(2,6-dimethylstyryl)phenyl)-N-methylpropanamide
• 英文别名: 3-[3-[(E)-2-(2,6-dimethylphenyl)ethenyl]phenyl]-N-methylpropanamide
• CAS: 1075176-11-2
• 化学式: C₂₀H₂₃NO
• 分子量: 293.409
• InChiKey: GECHQSKFNCMMPP-ZRDIBKRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS
  申请人：Scott Ian Leslie

  公开号：US20120129860A1

  公开（公告）日：2012-05-24

  The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

  本发明通常涉及用于治疗神经退行性疾病和障碍的组合物和方法，特别是用于治疗眼科疾病和障碍。本文提供了包括但不限于苯乙烯衍生物化合物和含有这些化合物的组合物，这些化合物对于治疗和预防眼科疾病和障碍，包括年龄相关性黄斑退化（AMD）和Stargardt病都非常有用。
• Styrenyl Derivative Compounds for Treating Ophthalmic Diseases and Disorders
  申请人：Acucela Inc.

  公开号：US20150166494A1

  公开（公告）日：2015-06-18

  The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

  本发明涉及一般用于治疗神经退行性疾病和紊乱的组合物和方法，特别是用于治疗眼科疾病和紊乱。本文提供了包括但不限于苯乙烯衍生物化合物和含有这些化合物的组合物，这些化合物可用于治疗和预防眼科疾病和紊乱，包括老年性黄斑变性（AMD）和Stargardt病。
• Styrenyl derivative compounds for treating ophthalmic diseases and disorders
  申请人：Acucela Inc.

  公开号：US10201545B2

  公开（公告）日：2019-02-12

  The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

  本发明一般涉及治疗神经退行性疾病和失调，特别是眼科疾病和失调的组合物和方法。本发明提供了苯乙烯基衍生物化合物，包括但不限于二苯乙烯基衍生物化合物，以及包含这些化合物的组合物，可用于治疗和预防眼科疾病和失调，包括老年性黄斑变性（AMD）和Stargardt病。
• US8420863B2
  申请人：——

  公开号：US8420863B2

  公开（公告）日：2013-04-16
• US8653142B2
  申请人：——

  公开号：US8653142B2

  公开（公告）日：2014-02-18