Methyl 2-acetyloxy-5-[2-(4-methylphenyl)ethylamino]benzoate | 1042742-29-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 2-acetyloxy-5-[2-(4-methylphenyl)ethylamino]benzoate
• CAS: 1042742-29-9
• 化学式: C₁₉H₂₁NO₄
• 分子量: 327.38
• InChiKey: OFZAXEXJOXTRNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 2-acetyloxy-5-[2-(4-methylphenyl)ethylamino]benzoate 在 盐酸 、 溶剂黄146 作用下， 反应 6.0h， 以90%的产率得到2-Hydroxy-5-[2-(4-methylphenyl)ethylamino]benzoic acid
  参考文献：
  名称：

  A New Route of Synthesis of 5‐(N‐Phenethylamino)salicylic Acid Derivatives by Rapid and Selective Reduction of the Amide Group with NaBH₄/Acetic Acid

  摘要：

  A good yield of 5-(N-phenethylamino)salicylic acid derivatives was successfully obtained from the corresponding methyl 2-acetoxy-5-(N-phenethylamino)benzoate esters by rapid and selective reduction of the amide group in the acyl protected salicylic acid with NaBH(4)/acetic acid in dioxane followed by hydrolysis of the ester group.

  DOI：

  10.1080/00397910801982001
• 作为产物：
  描述：

  Methyl 2-acetyloxy-5-[[2-(4-methylphenyl)acetyl]amino]benzoate 在 sodium tetrahydroborate 、 溶剂黄146 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.33h， 以64%的产率得到Methyl 2-acetyloxy-5-[2-(4-methylphenyl)ethylamino]benzoate
  参考文献：
  名称：

  A New Route of Synthesis of 5‐(N‐Phenethylamino)salicylic Acid Derivatives by Rapid and Selective Reduction of the Amide Group with NaBH₄/Acetic Acid

  摘要：

  A good yield of 5-(N-phenethylamino)salicylic acid derivatives was successfully obtained from the corresponding methyl 2-acetoxy-5-(N-phenethylamino)benzoate esters by rapid and selective reduction of the amide group in the acyl protected salicylic acid with NaBH(4)/acetic acid in dioxane followed by hydrolysis of the ester group.

  DOI：

  10.1080/00397910801982001

文献信息

• Pharmaceutical Composition for Treating or Preventing Degenerative and Inflammatory Diseases
  申请人：GWAG Byoung-Joo

  公开号：US20120209025A1

  公开（公告）日：2012-08-16

  The present invention relates to a pharmaceutical composition useful for treating or preventing inflammatory disease and cell damage, and a method for treating or preventing inflammatory disease and cell damage. The present invention uses the 2-hydroxybenzoic acid derivative represented by the specific chemical formula or its pharmaceutically acceptable salt. The compound of the present invention is useful for treating or preventing cell damage and inflammatory disease including gastritis, gastric ulcer, pancreatitis, colitis, arthritis, diabetes, arteriosclerosis, nephritis, hepatitis, Alzheimer's disease, Parkinson's disease and Lou Gehrig's disease.

  本发明涉及一种用于治疗或预防炎症性疾病和细胞损伤的药物组合物，以及一种治疗或预防炎症性疾病和细胞损伤的方法。本发明使用特定化学式所表示的2-羟基苯甲酸衍生物或其药学上可接受的盐。本发明的化合物用于治疗或预防包括胃炎、胃溃疡、胰腺炎、结肠炎、关节炎、糖尿病、动脉硬化、肾炎、肝炎、阿尔茨海默病、帕金森病和路易·格·埃里希病在内的细胞损伤和炎症性疾病。