N-(tetrahydro-3-furanyl)methyl-N'-cyano(methylthio)formamidine | 165252-98-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: N-(tetrahydro-3-furanyl)methyl-N'-cyano(methylthio)formamidine
• 英文别名: methyl N-cyano-N'-(oxolan-3-ylmethyl)carbamimidothioate
• CAS: 165252-98-2
• 化学式: C₈H₁₃N₃OS
• 分子量: 199.277
• InChiKey: ZOSOPTAGKOZRGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  82.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Furanyl insecticide
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0649845A1

  公开（公告）日：1995-04-26

  The present invention relates to novel (tetrahydro-3-furanyl)methylamino derivatives of the following formula (1): where X₁, X₂, X₃, X₄, X₅, X₆ and X₇ represent each a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, R₁ represents a hydrogen atom, an alkyl group having from 1 to 5 carbon atoms, an alkenyl group having 3 carbon atoms, a benzyl group, an alkoxyalkyl group having from 2 to 4 carbon atoms (in its whole group), an alkyloxycarbonyl group having from 1 to 3 carbon atoms in its alkyloxy portion, a phenoxy carbonyl group, an alkylcarbonyl group having from 1 to 6 carbon atoms in its alkyl portion, an alkenylcarbonyl group having from 2 to 3 carbon atoms in its alkenyl portion, a cycloalkylcarbonyl group having from 3 to 6 carbon atoms in its cycloalkyl portion, a benzoyl group, a benzoyl group substituted by 1 to 3 alkyl group(s) having from 1 to 4 carbon atoms, a benzoyl group substituted by 1 to 3 halogen atom(s), a 2-furanylcarbonyl group or an N,N-dimethylcarbamoyl group; R₂ represents a hydrogen atom, an amino group, a methyl group, an alkylamino group having from 1 to 5 carbon atoms, a di-substituted alkylamino group having from 2 to 5 carbon atoms (in its whole group), a 1-pyrrolidinyl group, an alkenylamino group having 3 carbon atoms, an alkynylamino group having 3 carbon atoms, a methoxyamino group, an alkoxyalkylamino group having from 2 to 4 carbon atoms (in its whole group), a methylthio group, or -N(Y₁)Y₂ (where Y₁ represents an alkyloxycarbonyl group having from 1 to 3 carbon atoms in its alkyloxy portion, a phenoxycarbonyl group, an alkylcarbonyl group having from 1 to 6 carbon atoms in its alkyl portion, an alkenylcarbonyl group having from 2 to 3 carbon atoms in its alkenyl portion, a cycloalkylcarbonyl group having from 3 to 6 carbon atoms in its cycloalkyl group, a benzoyl group, a benzoyl group substituted by 1 to 3 alkyl group(s) having form 1 to 4 carbon atoms, a benzoyl group substituted by 1 to 3 halogen atom(s), a 2-furanylcarbonyl group, a an N,N-dimethylcarbamoyl group, a (tetrahydro-3-furanyl)methyl group or a benzyl group, and Y₂ represents a hydrogen atom or an alkyl group having from 1 to 5 carbon atoms); and Z represents =N-NO₂, =CH-NO₂ or =N-CN, and insecticides containing the derivatives as an effective ingredient.

  本发明涉及下式（1）的新型（四氢-3-呋喃基）甲氨基衍生物： 其中 X₁、X₂、X₃、X₄、X₅、X₆ 和 X₇ 分别代表氢原子或具有 1 至 4 个碳原子的烷基，R₁ 代表氢原子、具有 1 至 5 个碳原子的烷基具有 3 个碳原子的烯基、苄基、具有 2 至 4 个碳原子（全基）的烷氧基烷基、其烷氧基部分具有 1 至 3 个碳原子的烷氧羰基、苯氧基羰基、烷基部分含有 1 至 6 个碳原子的烷基羰基、烯基部分含有 2 至 3 个碳原子的烯基羰基、环烷基部分含有 3 至 6 个碳原子的环烷基羰基、苯甲酰基、被 1 至 3 个含有 1 至 4 个碳原子的烷基取代的苯甲酰基、被 1 至 3 个卤素原子取代的苯甲酰基、2-呋喃基羰基或 N,N-二甲基氨基甲酰基；R₂ 代表氢原子、氨基、甲基、具有 1 至 5 个碳原子的烷基氨基、具有 2 至 5 个碳原子（全基）的二取代烷基氨基、1-吡咯烷基、具有 3 个碳原子的烯基氨基、具有 3 个碳原子的烷基氨基、甲氧基氨基、具有 2 至 4 个碳原子（全基）的烷氧基烷基氨基、甲硫基或 -N(Y₁)Y₂（其中 Y₁ 代表烷氧基部分具有 1 至 3 个碳原子的烷氧基羰基、苯氧基羰基、在其烷基部分中具有 1 至 6 个碳原子的烷基羰基、在其烯基部分中具有 2 至 3 个碳原子的烯基羰基、在其环烷基中具有 3 至 6 个碳原子的环烷基羰基、苯甲酰基、被 1 至 3 个具有 1 至 4 个碳原子的烷基取代的苯甲酰基、被 1 至 3 个卤素原子取代的苯甲酰基、2-呋喃基羰基、N,N-二甲基氨基甲酰基、（四氢-3-呋喃基）甲基或苄基，且 Y₂ 代表氢原子或具有 1 至 5 个碳原子的烷基；和 Z 代表 =N-NO₂、=CH-NO₂ 或 =N-CN，以及含有这些衍生物作为有效成分的杀虫剂。
• COMPOSITIONS AND USES THEREOF FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS
  申请人：Ceva Santé Animale

  公开号：EP3120846A1

  公开（公告）日：2017-01-25

  The invention relates to novel veterinary compositions comprising an effective amount of a neonicotinoid compound and an effective amount of a N-arylpyrazole compound. The invention also relates to the use of such compositions for controlling ectoparasites in a non-human mammal.

  本发明涉及新型兽用组合物，该组合物包含有效量的新烟碱化合物和有效量的 N-芳基吡唑化合物。本发明还涉及使用此类组合物控制非人类哺乳动物的体外寄生虫。
• METHODS AND MEANS FOR THE ERADICATION OF FLEAS
  申请人：Ceva Santé Animale

  公开号：EP3183968A1

  公开（公告）日：2017-06-28

  The invention relates to the use of a veterinary composition comprising an effective dose of a fast kill compound, such as a neonicotinoid compound, for the eradication of fleas from the living or accommodation areas of companion animals.

  本发明涉及一种兽用组合物的用途，该组合物包含有效剂量的快速杀灭化合物，如新烟碱化合物，用于消灭伴侣动物生活或住宿区域的跳蚤。
• METHODS FOR CONTROLLING ECTOPARASITES IN NON-HUMAN MAMMALS
  申请人：Ceva Santé Animale

  公开号：EP3259990A1

  公开（公告）日：2017-12-27

  The present invention relates to novel methods of treatment in the field of veterinary medicine, particularly methods for controlling ectoparasites in non-human mammals.

  本发明涉及兽医领域的新型治疗方法，特别是控制非人类哺乳动物体外寄生虫的方法。
• Methods for controlling the spread of dirofilariosis
  申请人：Ceva Santé Animale

  公开号：US10952988B2

  公开（公告）日：2021-03-23

  This invention relates to a method of controlling the spread of dirofilariosis, such as for example heartworm, by administering to at least one non-human animal infested with filarioid nematodes such as Dirofilaria spp or susceptible to have been infested with filarioid nematodes such as Dirofilaria spp, an effective dose of a combination of a neonicotinoid compound and a pyrethroid compound.

  本发明涉及一种控制双丝虫病（例如心丝虫）传播的方法，其方法是对至少一种感染了丝状线虫（例如双丝虫）或易感染丝状线虫（例如双丝虫）的非人类动物施用有效剂量的新烟碱类化合物和拟除虫菊酯类化合物的复合物。