硫胺盐酸盐磷酸盐 | 16028-14-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 硫胺盐酸盐磷酸盐
• 中文别名: 硫胺盐酸磷酸酯
• 英文名称: thiamine monophosphate chloride hydrochloride
• 英文别名: thiaminyl monophosphate；2-[3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl hydrogen phosphate;dihydrochloride；2-[3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl hydrogen phosphate;dihydrochloride
• CAS: 16028-14-1
• 化学式: C₁₂H₁₈N₄O₄PS*ClH*Cl
• 分子量: 417.253
• InChiKey: FRSZYKKDWVPUFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.85
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  151
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  硫胺盐酸盐磷酸盐 在 K-Na phosphate buffer 、 cytochrome c 作用下， 以 水 为溶剂， 生成 phosphoric acid mono-[2-(2,7-dimethyl-5H-pyrimido[4,5-d]thiazolo[3,2-a]pyrimidin-8-yl)-ethyl] ester
  参考文献：
  名称：

  摘要：

  The kinetics of reduction of ferricytochrome c in its reaction with thiamine and its O-substituted structural analogs in phosphate buffer at pH 7.5-7.8 were studied. The reduction rate is proportional to the concentration of thiamine or its derivatives. The dependence of the reaction rate on the oxidant concentration is characterized by negative deviations from linearity. In oxidation with ferricytochrome c, the reactivity of thiamine consdierably exceeds the reactivity of thiamine diphosphate and thiamine monophosphate, and in oxidation with ferricyanide the reaction rate increases in the order thiamine monophosphate < thiamine < thiamine diphosphate. With O-(2-norbornoyl)thiamine, O-(2-adamantyl)acetylthiamine, O-benzoylthiamine, O-(4-nitrobenzoyl)thiamine, or O-(5-nitro-2-chlorobenzoyl)thiamine, the rate of ferricytochrome c reduction is higher than with thiamine. Presumably, the electron transfer to the heme group of the oxidant is preceded by formation of a complex of ferricytochrome c with the neutral tricyclic form of the substrate.

  DOI：

  10.1023/a:1023361817590
• 作为产物：
  描述：

  盐酸硫胺 在 三氯氧磷 作用下， 反应 1.0h， 生成 硫胺盐酸盐磷酸盐
  参考文献：
  名称：

  [EN] SELECTIVE SOLVENT FREE PHOSPHORYLATION
  [FR] PHOSPHORYLATION SÉLECTIVE SANS SOLVANT

  摘要：

  提供了一种合成过程，用于制备磷酸化烟酰胺核糖苷（"NR"）的类似物，其化学式为（I），或其盐，以及具有化学式（II）的还原或改性衍生物，其中X-、Y1、Y2、Z1、Z2、n、R1、R2、R3、R4、R5、R6和R7如本文所定义。本公开还涉及制备烟酸核糖苷（"NAR"）的磷酸化类似物，其化学式为（I），或其盐，以及具有化学式（II）的还原或改性衍生物。通常使用适当的机械化学技术在无溶剂条件下进行操作。

  公开号：

  WO2016196941A1

文献信息

• Borehole fluid with a thiamine-based shale inhibitor
  申请人：Halliburton Energy Services, Inc.

  公开号：US11248156B2

  公开（公告）日：2022-02-15

  A subterranean product extraction composition may include a borehole fluid that may include a thiamine based shale inhibitor active to inhibit reactivity of a formation shale to a base fluid of a borehole fluid. A method of extracting a subterranean product via a borehole may include providing a borehole fluid containing a thiamine-based shale inhibitor and inhibiting reactivity of a formation shale contacted with the borehole fluid. A system for extracting a subterranean product via a borehole may include a tubular having an end in proximity to a formation shale and in fluid communication with a container dispensing a borehole fluid containing a thiamine-based shale inhibitor. The thiamine-based shale inhibitor is inert to the borehole fluid and has superior activity as compared to potassium chloride to inhibit shale reactivity. The borehole fluid may be a drilling fluid. The base fluid may be water.

  一种地下产品提取组合物可包括一种井眼流体，该井眼流体可包括一种硫胺基页岩抑制剂，该硫胺基页岩抑制剂具有抑制地层页岩与井眼流体基液反应的活性。通过井眼提取地下产品的方法可包括提供含有硫胺基页岩抑制剂的井眼流体，并抑制与井眼流体接触的地层页岩的反应性。一种通过井眼提取地下产品的系统可包括一个管状物，其一端靠近地层页岩，并与分配含有硫胺基页岩抑制剂的井眼流体的容器进行流体连通。硫胺基页岩抑制剂对井眼流体是惰性的，与氯化钾相比，硫胺基页岩抑制剂在抑制页岩反应性方面具有更高的活性。井眼流体可以是钻井液。基液可以是水。
• 含硫类化合物、其药物组合物及应用
  申请人：上海日馨医药科技股份有限公司

  公开号：CN117417301A

  公开（公告）日：2024-01-19

  本发明公开了一种含硫类化合物、其药物组合物及应用。本发明提供了一种物质A在制备Aβ40和/或Aβ42蛋白抑制剂或药物中的应用；所述的药物为用于治疗和/或由Aβ40和/或Aβ42蛋白介导的疾病的药物或者用于治疗和/或预防神经退行性疾病或衰老的药物，所述的物质A选自如式A1等所示的化合物或其药学上可接受的盐。本发明的化合物，对Aβ40及Aβ42蛋白具有良好的抑制作用，有望治疗和/或预防神经退行性疾病或衰老药物。#imgabs0#
• Compositions and Methods for Maintaining, Strengthening, Improving, or Promoting Eye Health
  申请人：Amico Valentina

  公开号：US20080181972A1

  公开（公告）日：2008-07-31

  Compositions for maintaining, strengthening, improving, or promoting eye health comprise α-lipoic acid, ascorbic acid, and α-tocopherol, or pharmaceutical equivalents thereof. The compositions are useful to prevent, stabilize, reverse and/or treat visual acuity loss in subjects having, or being at risk of developing, an ocular disease. The compositions can further comprise one or more other antioxidants, beneficial minerals, and/or nutritional or dietary materials.
• BOREHOLE FLUID WITH A THIAMINE-BASED SHALE INHIBITOR
  申请人：Halliburton Energy Services, Inc.

  公开号：US20210095179A1

  公开（公告）日：2021-04-01

  A subterranean product extraction composition may include a borehole fluid that may include a thiamine based shale inhibitor active to inhibit reactivity of a formation shale to a base fluid of a borehole fluid. A method of extracting a subterranean product via a borehole may include providing a borehole fluid containing a thiamine-based shale inhibitor and inhibiting reactivity of a formation shale contacted with the borehole fluid. A system for extracting a subterranean product via a borehole may include a tubular having an end in proximity to a formation shale and in fluid communication with a container dispensing a borehole fluid containing a thiamine-based shale inhibitor. The thiamine-based shale inhibitor is inert to the borehole fluid and has superior activity as compared to potassium chloride to inhibit shale reactivity. The borehole fluid may be a drilling fluid. The base fluid may be water.
• [EN] COMPOSITIONS AND METHODS FOR MAINTAINING, STRENGTHENING, IMPROVING OR PROMOTING EYE HEALTH<br/>[FR] COMPOSITIONS ET PROCÉDÉS DESTINÉS À MAINTENIR, RENFORCER, AMÉLIORER OU FAVORISER LA SANTÉ DES YEUX
  申请人：BAUSCH & LOMB

  公开号：WO2008094825A2

  公开（公告）日：2008-08-07

  [EN] Compositions for maintaining, strengthening, improving, or promoting eye health comprise a-lipoic acid, ascorbic acid, and a-tocopherol, or pharmaceutical equivalents thereof. The compositions are useful to prevent, stabilize, reverse and/or treat visual acuity loss in subjects having, or being at risk of developing, an ocular disease. The compositions can further comprise one or more other antioxidants, beneficial minerals, and/or nutritional or dietary materials.
  [FR] Selon la présente invention, les compositions permettant de maintenir, renforcer, améliorer ou favoriser la santé des yeux contiennent de l'acide a-lipoïque, de l'acide ascorbique et du a-tocophérol, ou des équivalents pharmaceutiques de ces composés. Les compositions se révèlent utiles pour prévenir, stabiliser, inverser et/ou traiter une perte de l'acuité visuelle chez des patients souffrant ou courant le risque de développer une maladie oculaire. Les compositions peuvent en outre contenir un ou plusieurs autres antioxydants, des minéraux bénéfiques, et/ou des matières nutritionnelles ou alimentaires.