3,6-dichloro-9-(4-chlorophenyl)-9H-fluoren-9-ol | 1422130-61-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 3,6-dichloro-9-(4-chlorophenyl)-9H-fluoren-9-ol
• 英文别名: 3,6-Dichloro-9-(4-chlorophenyl)fluoren-9-ol；3,6-dichloro-9-(4-chlorophenyl)fluoren-9-ol
• CAS: 1422130-61-7
• 化学式: C₁₉H₁₁Cl₃O
• 分子量: 361.655
• InChiKey: HBHKMBFAODXMDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4,4',4'-三氯三苯甲基乙醇 在 bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] 、 copper(II) acetate monohydrate 作用下， 以 十二烷 为溶剂， 反应 8.0h， 以73%的产率得到3,6-dichloro-9-(4-chlorophenyl)-9H-fluoren-9-ol
  参考文献：
  名称：

  Rhodium- and Iridium-Catalyzed Dehydrogenative Cyclization through Double C–H Bond Cleavages To Produce Fluorene Derivatives

  摘要：

  The rhodium-catalyzed cyclization of a series of 2,2-diarylalkanoic acids in the presence of copper acetate as an oxidant smoothly proceeded through double C-H bond cleavages and subsequent decarboxylation to produce the corresponding fluorene derivatives. The direct cyclization of triarylmethanols also took place efficiently by using an iridium catalyst in place of the rhodium, while the hydroxy function was still intact.

  DOI：

  10.1021/jo4000465

文献信息

• Rhodium- and Iridium-Catalyzed Dehydrogenative Cyclization through Double C–H Bond Cleavages To Produce Fluorene Derivatives
  作者：Masaki Itoh、Koji Hirano、Tetsuya Satoh、Yu Shibata、Ken Tanaka、Masahiro Miura

  DOI：10.1021/jo4000465

  日期：2013.2.15

  The rhodium-catalyzed cyclization of a series of 2,2-diarylalkanoic acids in the presence of copper acetate as an oxidant smoothly proceeded through double C-H bond cleavages and subsequent decarboxylation to produce the corresponding fluorene derivatives. The direct cyclization of triarylmethanols also took place efficiently by using an iridium catalyst in place of the rhodium, while the hydroxy function was still intact.