2-(3,5-dimethylbenzylselanyl)-5-nitrobenzaldehyde | 1350431-57-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3,5-dimethylbenzylselanyl)-5-nitrobenzaldehyde
• 英文别名: 2-[(3,5-Dimethylphenyl)methylselanyl]-5-nitrobenzaldehyde；2-[(3,5-dimethylphenyl)methylselanyl]-5-nitrobenzaldehyde
• CAS: 1350431-57-0
• 化学式: C₁₆H₁₅NO₃Se
• 分子量: 348.26
• InChiKey: FFFBCJBHVCVQMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.55
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,2-bis(3,5-dimethylbenzyl)diselane 、 2-氯-5-硝基苯甲醛 在 1,4-dithio-D,L-threitol 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以96%的产率得到2-(3,5-dimethylbenzylselanyl)-5-nitrobenzaldehyde
  参考文献：
  名称：

  셀레닐-치환된 방향족 알데하이드계 화합물의 신규 제조 방법

  摘要：

  本发明涉及一种关于硒基取代的芳香醛类化合物的新制备方法，具体来说，涉及一种形成硒醇酸盐亲核体从而对芳香醛类起始物质进行亲核取代的新制备方法。

  公开号：

  KR20170038770A

文献信息

• 셀레닐-치환된 방향족 알데하이드계 화합물의 신규 제조 방법
  申请人：INDUSTRY ACADEMY COOPERATION FOUNDATION OF SEJONG UNIVERSITY 세종대학교산학협력단(220050114702) BRN ▼206-82-07591

  公开号：KR20170038770A

  公开（公告）日：2017-04-07

  본원은, 셀레닐-치환된 방향족 알데하이드(selenyl-substituted aromatic aldehyde)계 화합물의 신규한 제조 방법에 관한 것으로서, 구체적으로, 셀레놀레이트 친핵체(selenolate nucleophile)를 형성하여 방향족 알데하이드계 출발물질을 친핵성 치환시키는 것을 포함하는, 셀레닐-치환된 방향족 알데하이드계 화합물의 신규한 제조 방법에 관한 것이다.

  本发明涉及一种关于硒基取代的芳香醛类化合物的新制备方法，具体来说，涉及一种形成硒醇酸盐亲核体从而对芳香醛类起始物质进行亲核取代的新制备方法。
• Mild generation of selenolate nucleophiles by thiol reduction of diselenides: convenient syntheses of selenyl-substituted aryl aldehydes
  作者：Rashmi Dubey、Hangeun Lee、Do-Hyun Nam、Dongyeol Lim

  DOI：10.1016/j.tetlet.2011.10.075

  日期：2011.12

  Various selenyl-substituted aryl aldehydes were obtained using dithiothreitol (DTT) as a reducing agent for diselenides in the presence of a base. For electron-deficient haloaryl aldehydes, a weak base, such as K2CO3, performed well. However, for electron-rich haloaryl aldehydes, a stronger base, such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), was required for successful substitution. The selenyl-substitution of heteroaryl substrates were also investigated to obtain satisfactory yields of the desired products. (C) 2011 Elsevier Ltd. All rights reserved.