1,3-Di-(2-chlorethyl)-uracil | 15816-11-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1,3-Di-(2-chlorethyl)-uracil
• 英文别名: 1,3-bis-(2-chloro-ethyl)-1H-pyrimidine-2,4-dione；1,3-Bis(2-chloroethyl)pyrimidine-2,4-dione
• CAS: 15816-11-2
• 化学式: C₈H₁₀Cl₂N₂O₂
• 分子量: 237.086
• InChiKey: PIKSOOHYWBXOSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Transporter-targeted methods of diagnosis and treatment
  申请人：Zerangue Noa

  公开号：US20070231260A1

  公开（公告）日：2007-10-04

  Methods of treating a disease in a patient, methods of determining the presence of a disease in a patient, methods of determining whether a disease in a patient is suitable to be treated with a therapeutic agent, and methods of monitoring treatment of a disease in a patient comprising determining a level of expression of a transporter in cells of a tissue associated with the disease are disclosed. The methods include administering to a patient a diagnostic conjugate and/or therapeutic conjugate that are substrates for a transporter expressed by cells of a tissue associated with the disease. Kits comprising a diagnostic composition comprising a diagnostic conjugate that is a transporter substrate are also disclosed. In particular, methods and kits useful for diagnosing and treating cancer are disclosed.
• [EN] TRANSPORTER-TARGETED METHODS OF DIAGNOSIS AND TREATMENT<br/>[FR] DIAGNOSTIC ET TRAITEMENT A CIBLAGE PAR LE TRANSPORTEUR
  申请人：XENOPORT INC

  公开号：WO2007041268A2

  公开（公告）日：2007-04-12

  [EN] Methods of treating a disease in a patient, methods of determining the presence of a disease in a patient, methods of determining whether a disease in a patient is suitable to be treated with a therapeutic agent, and methods of monitoring treatment of a disease in a patient comprising determining a level of expression of a transporter in cells of a tissue associated with the disease are disclosed. The methods include administering to a patient a diagnostic conjugate and/or therapeutic conjugate that are substrates for a transporter expressed by cells of a tissue associated with the disease. Kits comprising a diagnostic composition comprising a diagnostic conjugate that is a transporter substrate are also disclosed. In particular, methods and kits useful for diagnosing and treating cancer are disclosed.
  [FR] La présente invention concerne la recherche et le traitement d'une pathologie chez un patient, l'évaluation de la pertinence de l'utilisation d'un agent thérapeutique contre une pathologie, et le suivi du traitement par évaluation d'un niveau d'expression d'un transporteur dans les cellules d'un tissu associé à la pathologie. En l'occurrence, on administre des conjugués de diagnostic et/ou thérapeutiques constituant les substrats d'un transporteur exprimé par les cellules d'un tissu associé à la pathologie. L'invention concerne également des nécessaires comprenant une composition diagnostic à base du conjugué de l'invention, et plus particulièrement des procédés et nécessaires convenant au diagnostic et au traitement du cancer.