6-Bromo-3,4-dimethylpyridazine | 1520953-06-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-Bromo-3,4-dimethylpyridazine
• CAS: 1520953-06-3
• 化学式: C₆H₇BrN₂
• 分子量: 187.04
• InChiKey: CCSQHDUFFAISAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Substituted Tetrahydroquinolinone Compounds as ROR Gamma Modulators
  申请人：Aurigene Discovery Technologies Limited

  公开号：US20180200247A1

  公开（公告）日：2018-07-19

  The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of Retinoic acid receptor-related orphan receptors (RORs), more particularly as RORγ modulators. These compounds are useful in the treatment and prevention of diseases and/or disorder, in particular their use in diseases and/or disorder mediated by RORγ receptor. The present invention also provides preparation of the compounds and pharmaceutical formulations comprising at least one of the substituted tetrahydroquinolinone or related compounds of formula (I), together with a pharmaceutically acceptable carrier, diluent or excipient therefor.