3-benzyloxy-N-(4-fluorobenzyl)-5,6-dimethyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide | 871936-64-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-benzyloxy-N-(4-fluorobenzyl)-5,6-dimethyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide
• 英文别名: Benzyloxy-N-(4-fluorobenzyl)-5,6-dimethyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide；N-[(4-fluorophenyl)methyl]-5,6-dimethyl-4-oxo-3-phenylmethoxy-6,7-dihydropyrazolo[1,5-a]pyrazine-2-carboxamide
• CAS: 871936-64-0
• 化学式: C₂₃H₂₃FN₄O₃
• 分子量: 422.459
• InChiKey: QELNTNQEQQMZHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  76.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-benzyloxy-N-(4-fluorobenzyl)-5,6-dimethyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 生成 5,6-dimethyl-N-(4-fluorobenzyl)-3-hydroxy-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide
  参考文献：
  名称：

  Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors

  摘要：

  A series of 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides was synthesized and tested for their inhibition of HIV-1 integrase catalytic activity and HIV-1 replication in cells. Structure-activity studies around lead compound 5 indicated that a coplanar relationship of metal-binding heteroatoms provides optimal binding to the integrase active site. Identification of potency-enhancing substituents and adjustments in lipophilicity provided 17b which inhibits integrase-catalyzed strand transfer with an IC50 value of 74 nM and inhibits HIV-1 replication in cell culture in the presence of 50% normal human serum with an IC95 value of 63 nM. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.049
• 作为产物：
  描述：

  dimethyl 4-benzyloxy-1-(2-oxopropyl)-1H-pyrazole-3,5-dicarboxylate 在 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 7.0h， 生成 3-benzyloxy-N-(4-fluorobenzyl)-5,6-dimethyl-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamide
  参考文献：
  名称：

  [EN] HIV INTEGRASE INHIBITORS
  [FR] INHIBITEURS INTÉGRASE VIH

  摘要：

  公开号：

  WO2005120516A3

文献信息

• Hiv Integrase Inhibitors
  申请人：Wai S. John

  公开号：US20080015187A1

  公开（公告）日：2008-01-17

  Bicyclic pyrazoles of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein Z is O or N(R 8 ); n is an integer equal to zero or 1; and R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

  式I中的双环吡唑是HIV整合酶的抑制剂和HIV复制的抑制剂：其中Z是O或N（R8）; n是等于零或1的整数; R1、R2、R3、R4、R5、R6、R7和R8在此定义。这些化合物对预防和治疗HIV感染以及预防、延迟发病和治疗艾滋病非常有用。这些化合物可作为化合物本身或以药学上可接受的盐的形式用于对抗HIV感染和艾滋病。这些化合物及其盐可作为药物组成部分，可与其他抗病毒药物、免疫调节剂、抗生素或疫苗组合使用。
• HIV integrase inhibitors
  申请人：Merck & Co., Inc.

  公开号：US07476666B2

  公开（公告）日：2009-01-13

  Bicyclic pyrazoles of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: wherein Z is O or N(R8); n is an integer equal to zero or 1; and R1, R2, R3, R4, R5, R6, R7 and R8 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

  化合物I式的双环吡唑是HIV整合酶的抑制剂和HIV复制的抑制剂：其中Z为O或N（R8）; n是等于零或1的整数; R1，R2，R3，R4，R5，R6，R7和R8在此定义。这些化合物在预防和治疗HIV感染以及预防，延迟发病和治疗艾滋病方面非常有用。这些化合物可作为化合物本身或以药学上可接受的盐的形式用于抗击HIV感染和艾滋病。这些化合物及其盐可作为制药组合物中的成分，可与其他抗病毒药物，免疫调节剂，抗生素或疫苗组合使用。
• EP1758585A4
  申请人：——

  公开号：EP1758585A4

  公开（公告）日：2009-07-22
• HIV INTEGRASE INHIBITORS
  申请人：Merck & Co., Inc.

  公开号：EP1758585A2

  公开（公告）日：2007-03-07
• US7476666B2
  申请人：——

  公开号：US7476666B2

  公开（公告）日：2009-01-13