3-butoxy-4-hydroxy-7-ethoxycarbonylmethoxy-2H-1-benzopyran-2-one | 482287-89-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-butoxy-4-hydroxy-7-ethoxycarbonylmethoxy-2H-1-benzopyran-2-one
• 英文别名: Ethyl 2-(3-butoxy-4-hydroxy-2-oxochromen-7-yl)oxyacetate
• CAS: 482287-89-8
• 化学式: C₁₇H₂₀O₇
• 分子量: 336.342
• InChiKey: LTDLQKGZVOBUNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Benzopyran derivative and antiallergic agent
  申请人：Dainippon Ink and Chemicals, Inc.

  公开号：US20030096860A1

  公开（公告）日：2003-05-22

  The present invention provides a compound which is highly safe in terms of toxicity and has a stronger antiallergic action, and particularly has an action of inhibiting both immediate and delayed type allergic reactions. A benzopyran derivative represented by the general formula (I): 1 wherein R 1 is an alkyl group having 1-10 carbon atoms or an alkenyl group having 2-10 carbon atoms, and one of R 2 , R 3 , R 4 , and R 5 is an alkoxy group substituted with a hydroxy group or an alkoxy group substituted with a carboxy group, and the others are hydrogen atoms or physiologically acceptable salts thereof are superior as the active ingredient of an antiallergic agent.

  本发明提供了一种化合物，该化合物在毒性方面非常安全，并具有更强的抗过敏作用，特别是具有抑制即刻型和迟发型过敏反应的作用。一种由通式（I）表示的苯并吡喃衍生物：其中R1是具有1-10个碳原子的烷基或具有2-10个碳原子的烯基，而R2、R3、R4和R5中的一个是被羟基取代的烷氧基或被羧基取代的烷氧基，而其余的是氢原子，或其生理上可接受的盐作为抗过敏药物的活性成分。
• Benzopyran derivatives and antiallergic agent containing the same
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP1273578B1

  公开（公告）日：2005-02-23
• US6670391B2
  申请人：——

  公开号：US6670391B2

  公开（公告）日：2003-12-30