tert-butyl (1S,5S,6R)-[6-(2-(5-hydroxypyridin-3-yl)phenoxy)]-3-azabicyclo[3.2.1]octane-3-carboxylate | 1244772-79-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: tert-butyl (1S,5S,6R)-[6-(2-(5-hydroxypyridin-3-yl)phenoxy)]-3-azabicyclo[3.2.1]octane-3-carboxylate
• CAS: 1244772-79-9
• 化学式: C₂₃H₂₈N₂O₄
• 分子量: 396.486
• InChiKey: KVOHBZXLDBYFCG-HZUJVAHNSA-N

反应信息

• 作为反应物：
  描述：

  tert-butyl (1S,5S,6R)-[6-(2-(5-hydroxypyridin-3-yl)phenoxy)]-3-azabicyclo[3.2.1]octane-3-carboxylate 在 盐酸 作用下， 以 水 、 乙酸乙酯 为溶剂， 生成 rac-exo-[6-(2-(5-hydroxypyridin-3-yl)phenoxy)]-3-azabicyclo[3.2.1]octane hydrochloride
  参考文献：
  名称：

  A novel series of [3.2.1] azabicyclic biaryl ethers as α3β4 and α6/4β4 nicotinic receptor agonists

  摘要：

  We report the synthesis of a series of [3.2.1]azabicyclic biaryl ethers as selective agonists of alpha 3- and alpha 6-containing nicotinic receptors. In particular, compound 17a from this series is a potent alpha 3 beta 4 and alpha 6/4 beta 4 receptor agonist in terms of both binding and functional activity. Compound 17a also shows potent in vivo activity in CNS-mediated animal models that are sensitive to antipsychotic drugs. Compound 17a may thus be a useful tool for studying the role of alpha 3 beta 4 and alpha 6/4 beta 4 nicotinic receptors in CNS pharmacology. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.142
• 作为产物：
  描述：

  tert-butyl (1S,5S,6R)-[6-(2-(5-t-butoxycarbonyloxypyridin-3-yl)phenoxy)]-3-azabicyclo[3.2.1]octane-3-carboxylate 在 甲醇 、 lithium hydrochloride monohydrate 、 水 作用下， 以 四氢呋喃 为溶剂， 生成 tert-butyl (1S,5S,6R)-[6-(2-(5-hydroxypyridin-3-yl)phenoxy)]-3-azabicyclo[3.2.1]octane-3-carboxylate
  参考文献：
  名称：

  A novel series of [3.2.1] azabicyclic biaryl ethers as α3β4 and α6/4β4 nicotinic receptor agonists

  摘要：

  We report the synthesis of a series of [3.2.1]azabicyclic biaryl ethers as selective agonists of alpha 3- and alpha 6-containing nicotinic receptors. In particular, compound 17a from this series is a potent alpha 3 beta 4 and alpha 6/4 beta 4 receptor agonist in terms of both binding and functional activity. Compound 17a also shows potent in vivo activity in CNS-mediated animal models that are sensitive to antipsychotic drugs. Compound 17a may thus be a useful tool for studying the role of alpha 3 beta 4 and alpha 6/4 beta 4 nicotinic receptors in CNS pharmacology. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.06.142