| 1220450-48-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 1220450-48-5
• 化学式: C₁₈H₁₃N₃O₄
• 分子量: 335.319
• InChiKey: PEOMITWORPBVLF-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  、 苄脒盐酸盐 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Efficient Assembly of 2,5,6-Substituted Pyrimidines via MgI₂-Mediated Morita−Baylis−Hillman Reaction

  摘要：

  A mild and efficient protocol for the synthesis of a 2,6-disubstituted pyrimidine-5-carboxylate library via a Morita-Baylis-Hillman (MBH) adduct is described. Herein, the three step methodology involves the use of substituted alpha-iodomethylene beta-keto ester intermediates obtained after oxidation of the MBH adducts, which are condensed with various types of amidine or guanidine derivatives, to generate the 2, 6-disubstituted pyrimidines-5-carboxylate libraries.

  DOI：

  10.1021/cc100001e