(S)-2-(4-(2-chlorophenyl)-6-methyl-2-oxopyridin-1(2H)-yl)-3-cyclohexyl-N-(thiazol-2-yl)propanamide | 1036206-72-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (S)-2-(4-(2-chlorophenyl)-6-methyl-2-oxopyridin-1(2H)-yl)-3-cyclohexyl-N-(thiazol-2-yl)propanamide
• 英文别名: (2S)-2-[4-(2-chlorophenyl)-2-methyl-6-oxopyridin-1-yl]-3-cyclohexyl-N-(1,3-thiazol-2-yl)propanamide
• CAS: 1036206-72-0
• 化学式: C₂₄H₂₆ClN₃O₂S
• 分子量: 456.008
• InChiKey: VDUBJKJDBSBNGF-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  90.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• GLUCOKINASE ACTIVATORS
  申请人：Cheruvallath Zacharia

  公开号：US20090105255A1

  公开（公告）日：2009-04-23

  Compounds of the following formula are provided for use with glucokinase: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
• Glucokinase Activators
  申请人：Cheruvallath Zacharia

  公开号：US20120252814A1

  公开（公告）日：2012-10-04

  Compounds of the following formula are provided for use with glucokinase: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
• US8163779B2
  申请人：——

  公开号：US8163779B2

  公开（公告）日：2012-04-24
• US8530499B2
  申请人：——

  公开号：US8530499B2

  公开（公告）日：2013-09-10