6-(4-chloro-phenyl)-3-[1-(1-methyl-azetidin-3-yl)-1H-indol-5-yl]-3H-pyrimidin-4-one | 1194732-12-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(4-chloro-phenyl)-3-[1-(1-methyl-azetidin-3-yl)-1H-indol-5-yl]-3H-pyrimidin-4-one
• 英文别名: 6-(4-Chlorophenyl)-3-[1-(1-methylazetidin-3-yl)indol-5-yl]pyrimidin-4-one
• CAS: 1194732-12-1
• 化学式: C₂₂H₁₉ClN₄O
• 分子量: 390.872
• InChiKey: YACSPKOVAPDDTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  40.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] AZETIDINE DERIVATIVES<br/>[FR] DÉRIVÉS D'AZÉTIDINE
  申请人：LUNDBECK & CO AS H

  公开号：WO2009137270A2

  公开（公告）日：2009-11-12

  The present invention relates to azetidine derivatives which bind to the MCH l receptor. In separate aspects, the subject invention is directed to uses of said compounds in the preparation of a pharmaceutical composition for the treatment of metabolic and CNS related disorders and to methods of treating said disorders comprising administering a therapeutically effective amount of a compound of the invention.