ethyl 2,7-dimethylimidazo[1,2-a]pyrimidine-3-carboxylate | 90830-09-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并[1，2-a]嘧啶
• 英文名称: ethyl 2,7-dimethylimidazo[1,2-a]pyrimidine-3-carboxylate
• CAS: 90830-09-4
• 化学式: C₁₁H₁₃N₃O₂
• 分子量: 219.243
• InChiKey: RFQYPAWRAHVZKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  56.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 2,7-dimethylimidazo[1,2-a]pyrimidine-3-carboxylate 在 氢氧化钾 、 氯化亚砜 、 氨 作用下， 以 乙醇 、 氯仿 为溶剂， 生成 2,7-Dimethylimidazo[1,2-a]pyrimidine-3-carboxamide
  参考文献：
  名称：

  Research on heterocyclic compounds — Part XXXIX. 2-Methylimidazo[1,2-a]pyrimidine-3-carboxylic derivatives: Synthesis and antiinflammatory activity

  摘要：

  The synthesis of a group of 2-methylimidazo[1,2-a]pyrimidine-3-carboxylic esters, acids and amides is described. The structures of new compounds are supported by H-1 and C-13 NMR spectre. These compounds were tested in vivo for their antiinflammatory, analgesic. and ulcerogenic activity. Eight new compounds out of fifteen showed remarkable dose-dependent antiinflammatory action in the carrageenan rat paw edema (1/2-1/3 x indomethacin) but weak analgesic activity in the acetic acid writhing test together with negligible ulcerogenic action. The new compounds were found to be lacking in inhibitory activity on cyclooxygenase in vitro. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(98)80005-6
• 作为产物：
  描述：

  2-氨基-4-甲基嘧啶 、 2-氯乙酰乙酸乙酯 以 乙醇 为溶剂， 反应 36.0h， 以18%的产率得到ethyl 2,7-dimethylimidazo[1,2-a]pyrimidine-3-carboxylate
  参考文献：
  名称：

  Abignente; Arena; Luraschi, Farmaco, Edizione Scientifica, 1984, vol. 39, # 5, p. 379 - 388

  摘要：

  DOI：

文献信息

• ABIGNENTE, E.;ARENA, F.;LURASCHI, E.;SATURNINO, C.;MARMO, E.;DE, ROSIS, A+, FARMACO. ED. SCI., 1984, 39, N 5, 379-388
  作者：ABIGNENTE, E.、ARENA, F.、LURASCHI, E.、SATURNINO, C.、MARMO, E.、DE, ROSIS, A+

  DOI：——

  日期：——
• Research on heterocyclic compounds — Part XXXIX. 2-Methylimidazo[1,2-a]pyrimidine-3-carboxylic derivatives: Synthesis and antiinflammatory activity
  作者：Sonia Laneri、Antonia Sacchia、Marina Gallitelli、Francesca Arena、Elena Luraschi、Enrico Abignente、Walter Filippelli、Francesco Rossi

  DOI：10.1016/s0223-5234(98)80005-6

  日期：1998.3

  The synthesis of a group of 2-methylimidazo[1,2-a]pyrimidine-3-carboxylic esters, acids and amides is described. The structures of new compounds are supported by H-1 and C-13 NMR spectre. These compounds were tested in vivo for their antiinflammatory, analgesic. and ulcerogenic activity. Eight new compounds out of fifteen showed remarkable dose-dependent antiinflammatory action in the carrageenan rat paw edema (1/2-1/3 x indomethacin) but weak analgesic activity in the acetic acid writhing test together with negligible ulcerogenic action. The new compounds were found to be lacking in inhibitory activity on cyclooxygenase in vitro. (C) Elsevier, Paris.
• Abignente; Arena; Luraschi, Farmaco, Edizione Scientifica, 1984, vol. 39, # 5, p. 379 - 388
  作者：Abignente、Arena、Luraschi、Saturnino、Marmo、De Rosis、Filippelli

  DOI：——

  日期：——