5-benzyl-2-thioxo-3-(m-tolyl)imidazolidin-4-one | 1083175-85-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-benzyl-2-thioxo-3-(m-tolyl)imidazolidin-4-one
• 英文别名: 5-Benzyl-3-(3-methylphenyl)-2-thioxoimidazolidin-4-one；5-benzyl-3-(3-methylphenyl)-2-sulfanylideneimidazolidin-4-one
• CAS: 1083175-85-2
• 化学式: C₁₇H₁₆N₂OS
• 分子量: 296.393
• InChiKey: FKRHBJZLWSGREQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-甲基-N-叔丁氧羰基-D-苯丙氨酸 在 4-二甲氨基吡啶 、 二乙胺 、 N,N-二异丙基乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 、 乙腈 为溶剂， 反应 27.25h， 生成 5-benzyl-2-thioxo-3-(m-tolyl)imidazolidin-4-one
  参考文献：
  名称：

  Microwave-Assisted Synthesis of 3,5-Disubstituted Thiohydantoins Using Functional Ionic Liquid as Soluble Support

  摘要：

  A new approach for the syntheses of 3,5-disubstituted thiohydantoins was described using functionalized ionic liquid as soluble support. The products were obtained in good yields and purities after cyclization-cleavage from the ionic-liquid-supported under microwave irradiation, the ionic-liquid-supported species can there be purified from the reaction mixture by simple washing, and no chromatographic purification were needed during the synthesis.

  DOI：

  10.3987/com-10-12086

文献信息

• Microwave-Assisted Synthesis of 3,5-Disubstituted Thiohydantoins Using Functional Ionic Liquid as Soluble Support
  作者：Chen Zhuo、Dong Xian、Xie Hui、Li Mei

  DOI：10.3987/com-10-12086

  日期：——

  A new approach for the syntheses of 3,5-disubstituted thiohydantoins was described using functionalized ionic liquid as soluble support. The products were obtained in good yields and purities after cyclization-cleavage from the ionic-liquid-supported under microwave irradiation, the ionic-liquid-supported species can there be purified from the reaction mixture by simple washing, and no chromatographic purification were needed during the synthesis.