4-{2-[3-methoxy-4-(4-methyl-piperazin-1-yl)-phenylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}-phenol | 1454654-82-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-{2-[3-methoxy-4-(4-methyl-piperazin-1-yl)-phenylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}-phenol
• 英文别名: 4-[2-[3-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl]phenol
• CAS: 1454654-82-0
• 化学式: C₂₃H₂₅N₇O₂
• 分子量: 431.497
• InChiKey: OSVVFNDMXCJQBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  91
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] TRIAZOLOPYRAZINE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZOLOPYRAZINE
  申请人：MERCK PATENT GMBH

  公开号：WO2013131609A1

  公开（公告）日：2013-09-12

  Compounds of the formula (I) in which R1, R2 and R4 have the meanings indicated in Claim 1, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.

  式(I)中R1、R2和R4具有权利要求1中所指示的含义的化合物是GCN2的抑制剂，可用于治疗癌症。
• TRIAZOLOPYRAZINE DERIVATIVES
  申请人：Merck Patent GmbH

  公开号：US20150051202A1

  公开（公告）日：2015-02-19

  Compounds of the formula I in which R 1 , R 2 and R 4 have the meanings indicated in Claim 1, are inhibitors of GCN2, and can be employed, inter alia, for the treatment of cancer.

  公式I中，R1、R2和R4的含义如权利要求1所示的化合物是GCN2的抑制剂，可以用于治疗癌症等疾病。
• PHARMACEUTICAL ANTIRETROVIRAL COMBINATIONS COMPRISING LAMIVUDINE, FESTINAVIR AND NEVIRAPINE
  申请人：Cipla Limited

  公开号：EP2822560A1

  公开（公告）日：2015-01-14
• [EN] PHARMACEUTICAL ANTIRETROVIRAL COMBINATIONS COMPRISING LAMIVUDINE, FESTINAVIR AND NEVIRAPINE<br/>[FR] COMBINAISONS PHARMACEUTIQUES ANTIRÉTROVIRALES COMPRENANT DE LA LAMIVUDINE, DU FESTINAVIR ET DE LA NÉVIRAPINE
  申请人：CIPLA LTD

  公开号：WO2013132208A1

  公开（公告）日：2013-09-12

  The present invention relates to a pharmaceutical antiretroviral composition comprising lamivudine, festinavir and nevirapine, to a process for preparing such a composition and to the use of such a composition for the treatment and/or prophylaxis of diseases caused by retroviruses, especially acquired immune deficiency syndrome or an HIV infection.