3-(decyloxy)-4-hydroxy-7-(methoxy)-2H-1-benzopyran-2-one | 197519-71-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-(decyloxy)-4-hydroxy-7-(methoxy)-2H-1-benzopyran-2-one
• 英文别名: 3-Decoxy-4-hydroxy-7-methoxychromen-2-one
• CAS: 197519-71-4
• 化学式: C₂₀H₂₈O₅
• 分子量: 348.439
• InChiKey: NGAHSKAIHIFKGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  25
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• BENZOPYRAN DERIVATIVE AND ANTIALLERGIC AGENT CONTAINING THE SAME AS ACTIVE INGREDIENT
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0598117A1

  公开（公告）日：1994-05-25

  An antiallergic agent with a low toxicity and an excellent efficacy, containing a benzopyran derivative represented by general formula (I) as the active ingredient, wherein R¹ and R² represent each hydrogen, acyl, C₁ to C₁₂ alkyl or C₂ to C₁₀ alkenyl; and R³ represents hydroxy, acyloxy, C₁ to C₁₀ alkoxy or C₂ to C₁₀ alkenyloxy.

  一种低毒、高效的抗过敏剂，含有通式(I)代表的苯并吡喃衍生物作为活性成分，其中R¹和R²分别代表氢、酰基、C₁至C₁₂烷基或C₂至C₁₀烯基；和 R³ 代表羟基、酰氧基、C₁至 C₁₀ 烷氧基或 C₂ 至 C₁₀ 烯氧基。
• Benzopyran derivative and use of said benzopyran derivative for treating heart disease
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0796854A1

  公开（公告）日：1997-09-24

  The present invention offers a safe and effective drug for heart diseases and a safe and effective use of a benzopyran derivative for treating heart diseases such as ischemic heart disease and cardiac arrhythmia. The use of a benzopyran derivative comprises administering a pathologically effective amount of a benzopyran derivative expressed by the following general formula (I): wherein R1 is an alkyl group or an alkenyl group, R2 is a hydrogen atom, an alkyl group, an alkyl group having at least one hydroxyl group, an alkenyl group, an acyl group or a glycosyl group; or physiologically acceptable salts thereof.

  本发明提供了一种安全有效的治疗心脏病的药物，以及一种苯并吡喃衍生物用于治疗缺血性心脏病和心律失常等心脏病的安全有效的用途。苯并吡喃衍生物的用途包括施用病理有效量的由下通式（I）表示的苯并吡喃衍生物： 其中 R1 是烷基或烯基，R2 是氢原子、烷基、至少有一个羟基的烷基、烯基、酰基或糖基；或其生理上可接受的盐。
• US5428059A
  申请人：——

  公开号：US5428059A

  公开（公告）日：1995-06-27
• US5981495A
  申请人：——

  公开号：US5981495A

  公开（公告）日：1999-11-09