2-(2-thienyl)butyric acid | 54955-40-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-(2-thienyl)butyric acid
• 英文别名: 'Acide(thienyl-2) ethyl acetique', 2--buttersaeure；Aethyl--essigsaeure；2-(thiophen-2-yl)butanoic acid；2-thiophen-2-yl-butyric acid；2-thiophen-2-ylbutanoic acid
• CAS: 54955-40-7
• 化学式: C₈H₁₀O₂S
• 分子量: 170.232
• InChiKey: QUGOBTBFBNXICO-UHFFFAOYSA-N

物化性质

• 沸点：
  161 °C(Press: 21 Torr)
• 密度：
  1.214±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  65.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-thienyl)butyric acid 在 硫酸 、 magnesium sulfate chiral-plannar ferrocenyl derivative 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 、 甲苯 为溶剂， 反应 48.75h， 生成 2-Ethyl-3-oxo-2-thiophen-2-yl-butyric acid isopropyl ester
  参考文献：
  名称：

  Catalytic Enantioselective Construction of All-Carbon Quaternary Stereocenters:  Synthetic and Mechanistic Studies of the C-Acylation of Silyl Ketene Acetals

  摘要：

  With the aid of an appropriate chiral catalyst, acyclic silyl ketene acetals react with anhydrides to furnish 1,3-dicarbonyl compounds that bear all-carbon quaternary stereocenters in good ee and yield. Mechanistic studies provide strong support for a catalytic cycle that involves activation of both the electrophile (anhydride -> acylpyridinium) and the nucleophile (silyl ketene acetal -> enolate).

  DOI：

  10.1021/ja043832w
• 作为产物：
  描述：

  ethyl-[2]thienyl-malonic acid diethyl ester 生成 2-(2-thienyl)butyric acid
  参考文献：
  名称：

  NABET, R.;ANDRES, S.

  摘要：

  DOI：

文献信息

• [EN] OXAZOLIDINONE DERIVATIVES, PROCESS FOR THEIR PREPERATION AND THEIR USE AS ANTIMYCOBACTERIAL AGENTS<br/>[FR] DERIVES D'OXAZOLIDINONE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION COMME AGENTS ANTIMYCOBACTERIENTS
  申请人：LUPIN LTD

  公开号：WO2004026848A1

  公开（公告）日：2004-04-01

  Novel compounds belonging to the class of oxazolidinones possessing potent antimycobacterial properties especially useful in the treatment of acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium-intracellular complex, M. fortuitum and M. kansai. The compound and its pharmaceutically acceptable salts thereof act as antibacterial agents. Also disclosed is a method for inhibiting growth of mycobacterial cells a well as a method of treating mycobacterial conditions such as Mycobacterium tuberculoses, drug resistant Mycobacterium tuberculosis, Mycobacterium avium-intracellular complex, M. fortuitum and M. kansai, comprising administering an antimycobacterially effective amount of the said compound and/or pharmaceutically acceptable salts thereof. There is also disclosed a process for the manufacture of the said compound or its pharmaceutically acceptable salts.

  新型化合物属于噁唑烷酮类，具有强效抗分枝杆菌特性，特别适用于治疗酸快速生长的微生物，如结核分枝杆菌、分枝杆菌内复合体、堪萨斯分枝杆菌和康萨分枝杆菌。该化合物及其药学上可接受的盐作为抗菌剂。还公开了一种抑制分枝杆菌细胞生长的方法，以及治疗结核分枝杆菌病、耐药性结核分枝杆菌、分枝杆菌内复合体、堪萨斯分枝杆菌和康萨分枝杆菌等分枝杆菌疾病的方法，包括给予所述化合物和/或其药学上可接受的盐的抗分枝杆菌有效量。还公开了一种制造所述化合物或其药学上可接受的盐的方法。
• Process for the preparation of poly-alpha-glutamic acid and derivatives thereof
  申请人：McKennon Marc

  公开号：US20080051603A1

  公开（公告）日：2008-02-28

  The invention relates to an improved process for the preparation of poly-α-glutamic acids which comprises the polymerization of tertiary γ-esters of α-glutamic acid N-carboxy anhydride with appropriate solvents and initiators, followed by acid hydrolysis of the resulting poly-α-glutamic acid-γ-ester. The process is particularly advantageous in that it allows one to carefully control the molecular weight of the resulting poly-α-glutamic acid. The invention also relates to poly-α-glutamic acids capped at the amino terminus with carboxylic acids or amino acids and to a process for the preparation thereof.

  该发明涉及一种改进的聚α-谷氨酸的制备过程，包括将α-谷氨酸N-羧酸酐的三级γ-酯与适当的溶剂和引发剂聚合，然后对所得的聚α-谷氨酸-γ-酯进行酸水解。该过程特别有利之处在于它允许精确控制所得聚α-谷氨酸的分子量。该发明还涉及在氨基末端带有羧酸或氨基酸的聚α-谷氨酸以及其制备过程。
• Survivin inhibitors
  申请人：Wendt D. Michael

  公开号：US20070072833A1

  公开（公告）日：2007-03-29

  Compounds that inhibit survivin, compositions containing the compounds and methods of treating diseases in which survivin is unregulated or overexpressed are disclosed.

  抑制survivin的化合物、含有这些化合物的组合物以及治疗survivin失调或过度表达疾病的方法被揭示。
• Highly Enantioselective Direct Alkylation of Arylacetic Acids with Chiral Lithium Amides as Traceless Auxiliaries
  作者：Craig E. Stivala、Armen Zakarian

  DOI：10.1021/ja205107x

  日期：2011.8.10

  A direct, highly enantioselective alkylation of arylacetic acids via enediolates using a readily available chiral lithium amide as a stereodirecting reagent has been developed. This approach circumvents the traditional attachment and removal of chiral auxiliaries used currently for this type of transformation. The protocol is operationally simple, and the chiral reagent is readily recoverable.

  已经开发出使用容易获得的手性氨基锂作为立体定向试剂通过烯二醇对芳基乙酸进行直接、高度对映选择性的烷基化。这种方法绕过了目前用于此类转化的手性助剂的传统附着和去除。该方案操作简单，手性试剂易于回收。
• Spiro-imidazolones for treatment of diabetic complications
  申请人：PFIZER INC.

  公开号：EP0171213A1

  公开（公告）日：1986-02-12

  Spiro-imidazolones of formula are disclosed wherein: X is oxygen or sulfur; Y is hydrogen, halo or alkyl and R is hydrogen, methyl or ethyl, which are useful as aldose reductase inhibitors and as therapeutic agents for the treatment of complications arising from diabetes. Pharmaceutical compositions containing the spiro compounds and a method of treating diabetic complications are also disclosed.

  公开了式中的螺咪唑啉酮，其中：X 为氧或硫；Y 为氢、卤代或烷基；R 为氢、甲基或乙基，它们可用作醛糖还原酶抑制剂和治疗糖尿病并发症的治疗剂。 还公开了含有螺化合物的药物组合物和治疗糖尿病并发症的方法。