2,4-dimethoxyethoxymethyloxyphenol | 312608-04-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2,4-dimethoxyethoxymethyloxyphenol
• 英文别名: 2,4-Bis(2-methoxyethoxymethoxy)phenol
• CAS: 312608-04-1
• 化学式: C₁₄H₂₂O₇
• 分子量: 302.324
• InChiKey: KWDMMXGCERJAHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  21
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2,4-dimethoxyethoxymethyloxyphenol 在 乙醇 、 水 、 potassium carbonate 、 对甲苯磺酸 、 4-羟乙基哌嗪乙磺酸 作用下， 以 丙酮 为溶剂， 反应 0.5h， 生成 1,2,4-苯三酚
  参考文献：
  名称：

  Light-Activated Regulation of Cofilin Dynamics Using a Photocaged Hydrogen Peroxide Generator

  摘要：

  Hydrogen peroxide (H2O2) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe for producing H2O2 on demand upon photoactivation and its application for optical regulation of cofilin-actin rod formation in living cells. This chemical method offers many potential opportunities for dissecting biological roles for H2O2 as well as remote control of cell behavior via H2O2-mediated pathways.

  DOI：

  10.1021/ja107783j
• 作为产物：
  描述：

  2,4-Bis<(2-methoxyethoxy)methoxy>benzaldehyd 在 间氯过氧苯甲酸 、 水 、 potassium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 4.5h， 以81%的产率得到2,4-dimethoxyethoxymethyloxyphenol
  参考文献：
  名称：

  A thermally-stable enzyme detection assay that amplifies signal autonomously in water without assistance from biological reagents

  摘要：

  本通讯介绍了一种热稳定小分子和相应的检测策略，当检测到特定酶生物标记物时，该策略可自主放大比色信号。

  DOI：

  10.1039/c2cc36861g

文献信息

• Enantioselective acylation of 2-hydroxymethyl-2,3-dihydrobenzofurans catalysed by lipase from Pseudomonas cepacia (Amano PS) and total stereoselective synthesis of (−)-(R)-MEM-protected arthrographol
  作者：S Ramadas、G.L.David Krupadanam

  DOI：10.1016/s0957-4166(00)00302-5

  日期：2000.8

  Lipase Amano PS catalysed acylation of (+/-)-2-hydroxymethyl-2,3-dihydrobenzofurans using vinyl acetate as the acyl donor in n-hexane gave (-)-(R)-2-acetoxymethyl-2,3-dihydrobenzo and (+)-(S)-2-hydroxymethyl-2,3-dihydrobenzofurans in high enantiomeric excess. (-)-(R)-Acetate 18j is converted to (-)-(R)-MEM-protected arthrographol 22. (C) 2000 Published by Elsevier Science Ltd.
• Light-Activated Regulation of Cofilin Dynamics Using a Photocaged Hydrogen Peroxide Generator
  作者：Evan W. Miller、Nicolas Taulet、Carl S. Onak、Elizabeth J. New、Julie K. Lanselle、Gillian S. Smelick、Christopher J. Chang

  DOI：10.1021/ja107783j

  日期：2010.12.8

  Hydrogen peroxide (H2O2) can exert diverse signaling and stress responses within living systems depending on its spatial and temporal dynamics. Here we report a new small-molecule probe for producing H2O2 on demand upon photoactivation and its application for optical regulation of cofilin-actin rod formation in living cells. This chemical method offers many potential opportunities for dissecting biological roles for H2O2 as well as remote control of cell behavior via H2O2-mediated pathways.
• A thermally-stable enzyme detection assay that amplifies signal autonomously in water without assistance from biological reagents
  作者：Kimy Yeung、Kyle M. Schmid、Scott T. Phillips

  DOI：10.1039/c2cc36861g

  日期：——

  This Communication describes a thermally-stable small molecule and a corresponding assay strategy that autonomously amplifies a colorimetric signal when a specific enzyme biomarker is detected.

  本通讯介绍了一种热稳定小分子和相应的检测策略，当检测到特定酶生物标记物时，该策略可自主放大比色信号。