N-((7-(diethylamino)-2-oxo-2H-chromen-3-yl)methylene)-2-(quinolin-8-yloxy)acetohydrazonic acid | 1428774-07-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: N-((7-(diethylamino)-2-oxo-2H-chromen-3-yl)methylene)-2-(quinolin-8-yloxy)acetohydrazonic acid
• CAS: 1428774-07-5
• 化学式: C₂₅H₂₄N₄O₄
• 分子量: 444.49
• InChiKey: UVVCFWNEYZCSRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.56
• 重原子数：
  33.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  100.52
• 氢给体数：
  1.0
• 氢受体数：
  7.0

文献信息

• Development of a novel fluorescent probe for copper ion in near aqueous media
  作者：Fengjuan Chen、Fengping Hou、Liang Huang、Ju Cheng、Hongyan Liu、Pinxian Xi、Decheng Bai、Zhengzhi Zeng

  DOI：10.1016/j.dyepig.2013.01.026

  日期：2013.7

  In this work, we have successfully provided a new fluorescent probe based on coumarin and quinoline (CQ) for detecting copper ion. This system utilizes such a chemical process, which responses instantaneously at room temperature with linear proportionality to the amount of copper ion. The receptor can be applied to monitoring of Cu2+ ion in aqueous solution with a pH span 5-11. The chemosensor CQ has a high fluorescence on/off ratio of over 48 and exhibits a high selectivity and sensitivity toward Cu2+ over other common metal ions in near aqueous media. And the compound CQ can easily stain living cells, having potential application in biology. (C) 2013 Elsevier Ltd. All rights reserved.