(+/-)-2-(2,4,6-trichloropyrimidin-5-yl)propyl methanesulfonate | 1312162-79-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (+/-)-2-(2,4,6-trichloropyrimidin-5-yl)propyl methanesulfonate
• 英文别名: 5-Pyrimidineethanol, 2,4,6-trichloro-beta-methyl-, 5-methanesulfonate；2-(2,4,6-trichloropyrimidin-5-yl)propyl methanesulfonate
• CAS: 1312162-79-0
• 化学式: C₈H₉Cl₃N₂O₃S
• 分子量: 319.596
• InChiKey: BLFLAOVDMHFTDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  77.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS<br/>[FR] DÉRIVÉS DE 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE COMME INHIBITEURS DE FAK/PYK2
  申请人：CENTAURUS BIOPHARMA CO LTD

  公开号：WO2012092880A1

  公开（公告）日：2012-07-12

  The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/ or Pyk2 mediated disorder or disease.

  这项发明涉及一种新型的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物，作为FAK和/或Pyk2抑制剂，以及它们的制备方法、组合物，以及利用这些化合物抑制FAK和/或Pyk2并治疗由FAK和/或Pyk2介导的疾病或疾病的方法。
• 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS
  申请人：Xiao Dengming

  公开号：US20130281438A1

  公开（公告）日：2013-10-24

  The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/or Pyk2 mediated disorder or disease.

  本发明涉及一种新型的2,4-二氨基-6,7-二氢-5H-吡咯[2,3]嘧啶衍生物，作为FAK和/或Pyk2抑制剂，以及它们的制备方法、组合物和化合物用于抑制FAK和/或Pyk2以及治疗FAK和/或Pyk2介导的疾病或疾病的方法。
• Polarizing plate and image display device including the same
  申请人：LG CHEM, LTD.

  公开号：US10353125B2

  公开（公告）日：2019-07-16

  The present disclosure relates to a polarizing plate including an adhesive layer, a primer layer and a polyethylene terephthalate film which are sequentially formed on at least one side of a polarizer, wherein the adhesive layer in the present disclosure is formed by an active energy ray-curable adhesive including a first epoxy compound of which a homopolymer has a glass transition temperature of 120° C. or higher, a second epoxy compound of which a homopolymer has a glass transition temperature of 60° C. or lower, and a cationic photopolymerization initiator, and wherein the primer layer is formed by a primer composition including one or more binder resins selected from the group consisting of polyester and polyvinyl alcohol-based resins, and one or more cross-linking agents selected from the group consisting of acrylic cross-linking agents, epoxy-based cross-linking agents and polyvinyl alcohol-based cross-linking agents.

  本公开涉及一种偏光板，包括粘合剂层、底涂层和聚对苯二甲酸乙二醇酯薄膜，它们依次形成于偏光板的至少一侧，其中，本公开中的粘合剂层由活性能量射线固化粘合剂形成，该粘合剂包括第一环氧化合物（其均聚物的玻璃化转变温度为120℃或更高）、第二环氧化合物（其均聚物的玻璃化转变温度为60℃或更低）和阳离子光聚合引发剂，其中，底涂层由底涂组合物形成，该底涂组合物包括一种或多种粘合剂树脂，该粘合剂树脂选自由聚酯和聚对苯二甲酸乙二醇酯组成的组。或更低的第二环氧化合物，以及阳离子光聚合引发剂，其中底漆层由底漆组合物形成，该底漆组合物包括选自由聚酯和聚乙烯醇基树脂组成的组中的一种或多种粘合剂树脂，以及选自由丙烯酸交联剂、环氧基交联剂和聚乙烯醇基交联剂组成的组中的一种或多种交联剂。
• ADHESIVE FOR POLARIZING PLATE AND POLARIZING PLATE INCLUDING THE SAME
  申请人：LG CHEM, LTD.

  公开号：US20140072731A1

  公开（公告）日：2014-03-13

  The present invention relates to an adhesive composition including 100 parts by weight of a first epoxy compound having a glass transition temperature of a homopolymer of not less than 120° C., 30 parts by weight to 100 parts by weight of a second epoxy compound having a glass transition temperature of a homopolymer of not more than 60° C., and 0.5 parts by weight to 20 parts by weight of a cationic photopolymerization initiator, and a polarizing plate using the same.
• POLARIZING PLATE AND IMAGE DISPLAY DEVICE INCLUDING THE SAME
  申请人：LG Chem, Ltd.

  公开号：US20160062010A1

  公开（公告）日：2016-03-03

  The present disclosure relates to a polarizing plate including an adhesive layer, a primer layer and a polyethylene terephthalate film which are sequentially formed on at least one side of a polarizer, wherein the adhesive layer in the present disclosure is formed by an active energy ray-curable adhesive including a first epoxy compound of which a homopolymer has a glass transition temperature of 120° C. or higher, a second epoxy compound of which a homopolymer has a glass transition temperature of 60° C. or lower, and a cationic photopolymerization initiator, and wherein the primer layer is formed by a primer composition including one or more binder resins selected from the group consisting of polyester and polyvinyl alcohol-based resins, and one or more cross-linking agents selected from the group consisting of acrylic cross-linking agents, epoxy-based cross-linking agents and polyvinyl alcohol-based cross-linking agents.