3-[2'-(4''-hydroxyphenyl)phenyl]propanal | 878996-38-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[2'-(4''-hydroxyphenyl)phenyl]propanal
• 英文别名: 3-[2-(4-Hydroxyphenyl)phenyl]propanal
• CAS: 878996-38-4
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: XCIZBGANGFLCSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-[2'-(4''-hydroxyphenyl)phenyl]propanal 、 甲醇 在 (R)-2-(dinaphthalen-2-yl-trimethylsilyloxymethyl)pyrrolidine 碘苯二乙酸 作用下， 反应 24.17h， 以75%的产率得到(4bR,8aS,9S)-4b-methoxy-7-oxo-4b,7,8,8a,9,10-hexahydrophenanthrene-9-carbaldehyde
  参考文献：
  名称：

  An Enantioselective Organocatalytic Oxidative Dearomatization Strategy

  摘要：

  We have developed a catalytic enantioselective strategy for chemical synthesis wherein flat aromatic molecules are directly converted to complex nonremmic molecular arch lectures. The process Involves oxidative dearomatization of substituted phenols followed by a desymmebrizing secondry amine-catalyzed asymmetric intermolecular Michael addition and reveals a declin structure formed with exquisite control of three now streogenic centers and an array of exploitable orthogonal functionality directly from a flat molecule that is devoid or architectural complexity.

  DOI：

  10.1021/ja077457u
• 作为产物：
  描述：

  4-[2'-(羟甲基)苯基]苯甲醚 在 三溴化硼 作用下， 以 二氯甲烷 、 水 、 乙腈 为溶剂， 反应 5.25h， 生成 3-[2'-(4''-hydroxyphenyl)phenyl]propanal
  参考文献：
  名称：

  联芳系统光生醌甲基化物的溶剂分解和闭环

  摘要：

  各种联芳基醌甲基化物已经从联芳基前体 4??6 和 8、10 和 11 以一系列效率光生，它们都具有交替的羟基和羟甲基取代基。

  DOI：

  10.1139/v05-138

文献信息

• An Enantioselective Organocatalytic Oxidative Dearomatization Strategy
  作者：Ngoc T. Vo、Robert D. M. Pace、Fionn O'Har、Matthew J. Gaunt

  DOI：10.1021/ja077457u

  日期：2008.1.1

  We have developed a catalytic enantioselective strategy for chemical synthesis wherein flat aromatic molecules are directly converted to complex nonremmic molecular arch lectures. The process Involves oxidative dearomatization of substituted phenols followed by a desymmebrizing secondry amine-catalyzed asymmetric intermolecular Michael addition and reveals a declin structure formed with exquisite control of three now streogenic centers and an array of exploitable orthogonal functionality directly from a flat molecule that is devoid or architectural complexity.
• Solvolysis and ring closure of quinone methides photogenerated from biaryl systems
  作者：Yijian Shi、Peter Wan

  DOI：10.1139/v05-138

  日期：2005.9.1

  A variety of biaryl quinone methides have been photogenerated with a range of efficiencies from biaryl precursors 4–6 and 8, 10, and 11, all having hydroxyl and hydroxymethyl substituents on altern...

  各种联芳基醌甲基化物已经从联芳基前体 4??6 和 8、10 和 11 以一系列效率光生，它们都具有交替的羟基和羟甲基取代基。