(E)-2,2-difluoro-1-methylethylidenebenzylamine | 1018435-09-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-2,2-difluoro-1-methylethylidenebenzylamine
• CAS: 1018435-09-0
• 化学式: C₁₀H₁₁F₂N
• 分子量: 183.201
• InChiKey: AJZKCZBXGUUREN-MDWZMJQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.91
• 重原子数：
  13.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  12.36
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  苄胺 、 (1,1-difluoroprop-1-en-2-yloxy)trimethylsilane 以 乙醚 为溶剂， 反应 80.0h， 生成 (E)-2,2-difluoro-1-methylethylidenebenzylamine
  参考文献：
  名称：

  Umpolung Reactivity of Difluoroenol Silyl Ethers with Amines and Amino Alcohols. Application to the Synthesis of Enantiopure α-Difluoromethyl Amines and Amino Acids

  摘要：

  Difluoroenol silyl ethers, produced in situ from acylsilanes and CF3TMS, react as electrophiles with amines to give difluoroimines, via the corresponding hemiaminal adduct, as evidenced by F-19 NMR spectroscopy. Reaction with (R)-phenylglycinol led to 2-difluoromethyloxazolidines. After separation of the diastereomers, reduction with LAH and Strecker-type synthesis gave enantiopure alpha-difluoromethy-lamines and alpha-difluoromethyl-alpha-amino acids, respectively.

  DOI：

  10.1021/jo702328v

文献信息

• [EN] PROCESS FOR PREPARING SUBSTITUTED PYRAZOLES CONTAINING HALOALKOXY- AND HALOALKYLTHIO GROUPS FROM α,α-DIHALOALKYLAMINES AND KETIMINES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE PYRAZOLES SUBSTITUÉS CONTENANT DES GROUPES HALOALCOXYTHIO ET HALOALKYLTHIO D'Α,Α-DIHALOALKYLAMINES ET CÉTIMINES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2016207167A1

  公开（公告）日：2016-12-29

  The present invention relates to a novel process for preparing 3,5 -bis substituted pyrazoles containing haloalkoxy- and haloalkylthio groups.

  本发明涉及一种制备含卤代烷氧基和卤代烷硫基的3,5-双取代吡唑的新工艺。
• [EN] PROCESS FOR PREPARING 3,5-BIS(HALOALKYL)PYRAZOLE DERIVATIVES FROM α,α-DIHALOAMINES AND KETIMINES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE 3,5-BIS(HALOALKYL)PYRAZOLE À PARTIR D'Α,Α-DIHALOAMINES ET DE CÉTIMINES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2015144578A1

  公开（公告）日：2015-10-01

  Process for preparine3,5-bis(haloalkyl)pyrazolederivatives from a,a-dihaloamines and ketimines The present invention relates to a novel process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines. Intermedaites used in the process are also claimed.

  从α,α-二卤胺和酮亚胺制备3,5-双(卤代烷基)吡唑衍生物的过程。本发明涉及一种从α,α-二卤胺和酮亚胺制备3,5-双(卤代烷基)吡唑衍生物的新方法。该过程中使用的中间体也被要求。
• [EN] PROCESS FOR PREPARING 3-FLUOROALKYL-5-PYRAZOLECARBOXYLATES AND 3-FLUOROALKYL-5-PYRAZOLECARBOXYLIC ACIDS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE 3-FLUOROALKYL-5-PYRAZOLECARBOXYLATES ET D'ACIDES 3-FLUOROALKYL-5-PYRAZOLECARBOXYLIQUE
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2018054807A1

  公开（公告）日：2018-03-29

  The present invention relates to a novel process for preparing 3-fluoroalkyl-5-pyrazolecarboxylates from ketimines and oxalic acid derivatives which can be further transformed into 3-fluoroalkyl-5- pyrazolecarboxylic acids.

  本发明涉及一种从酮亚胺和草酸衍生物制备3-氟烷基-5-吡唑羧酸酯的新工艺，该酯可以进一步转化为3-氟烷基-5-吡唑羧酸。
• [EN] PROCESS FOR PREPARING 3,5-BIS(HALOALKYL)PYRAZOLES VIA ACYLATION OF KETIMINES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE 3,5-BIS (HALOALKYL) PYRAZOLES PAR ACYLATION DE CÉTIMINES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2015189138A1

  公开（公告）日：2015-12-17

  The present invention relates to a novel process for preparing 3,5-bis(haloalkyl)pyrazole derivatives of the formula (Ia) and (Ib), via acylation of ketimines.

  本发明涉及一种制备3,5-双(卤代烷基)吡唑衍生物的新工艺，通过酰化酮亚胺得到化学式(Ia)和(Ib)的衍生物。
• Process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from a,a-dihaloamines and ketimines
  申请人：Bayer CropScience AG

  公开号：EP3015458A1

  公开（公告）日：2016-05-04

  The present invention relates to a novel process for preparing 3,5-bis(haloalkyl)pyrazole derivatives from α,α-dihaloamines and ketimines.

  本发明涉及一种从 α,α-二卤胺和酮亚胺制备 3,5-双（卤代烷基）吡唑衍生物的新工艺。