6β-methyl-5α-cholestane-3β,5α-diol | 1857-81-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 6β-methyl-5α-cholestane-3β,5α-diol
• 英文别名: 6β-methyl-5α-cholestanediol-(3β.5)；(10R)-3c.5t-Dihydroxy-6c.10r.13c-trimethyl-17c-((R)-1.5-dimethyl-hexyl)-(8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren；3β.5-Dihydroxy-6β.10.13-trimethyl-17β-((R)-1.5-dimethyl-hexyl)-5α-gonan；6β-Methyl-5α-cholestandiol-(3β.5)；6β-Methyl-5α-cholestan-3β,5-diol；(3S,5S,6R,8S,9S,10R,13R,14S,17R)-6,10,13-trimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,5-diol
• CAS: 1857-81-4
• 化学式: C₂₈H₅₀O₂
• 分子量: 418.704
• InChiKey: MHYKVQQPBSKDET-NORPZUAXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6β-methyl-5α-cholestane-3β,5α-diol 在 chromium(VI) oxide 、 硫酸 作用下， 生成 5α-hydroxy-6β-methylcholestan-3-one
  参考文献：
  名称：

  Julia,S.; Decouvelaere,B., Bulletin de la Societe Chimique de France, 1963, p. 2476 - 2480

  摘要：

  DOI：
• 作为产物：
  描述：

  cholesterol 在 过氧化氢苯甲酰 、 乙醚 、 氯仿 、 苯 作用下， 生成 6β-methyl-5α-cholestane-3β,5α-diol
  参考文献：
  名称：

  Interlocking Directorates: An Example of Tacit Knowledge Transfer

  摘要：

  This paper illustrates tacit knowledge flows between American and Canadian metropolitan areas. Using the spatial distribution of interlocking in Canada and the United States a spatial component is added to the resource dependency paradigm. Using a poisson regression model. components of cities that initiate and attract interlocking, and thus knowledge transfer, can be identified. From the results, the authors propose the concept of a "knowledge threshold" essential for the transfer of tacit knowledge. In Canada the "knowledge threshold" encompasses the entire country while it is more regionally based in the United States.

  DOI：

  10.2747/0272-3638.23.2.154

文献信息

• [EN] HALOGENATED CHOLESTEROL ANALOGUES AND METHODS OF MAKING AND USING SAME<br/>[FR] ANALOGUES HALOGÉNÉS DU CHOLESTÉROL ET LEURS PROCÉDÉS DE PRÉPARATION ET LEURS MÉTHODES D'UTILISATION
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2020069267A1

  公开（公告）日：2020-04-02

  Provided herein are halogenated cholesterol analogues, including methods of making and using the same. Also provided are methods of making radiolabeled cholesterol analogues including admixing an epoxide with a fluorine-18 source under conditions to form a radiofluorinated cholesterol analogue.

  本文提供了卤代胆固醇类似物，包括其制备和使用方法。还提供了制备放射标记胆固醇类似物的方法，包括在条件下将环氧化合物与氟-18源混合以形成放射氟标记的胆固醇类似物。
• The Photo-Beckmann Rearrangement of Steroidal β,γ-Unsaturated Ketone Oximes
  作者：Hiroshi Suginome、Norio Maeda、Yuko Takahashi、Nobuyoshi Miyata

  DOI：10.1246/bcsj.54.846

  日期：1981.3

  The photoreaction of 4,4-dimethylcholest-5-en-3-one oxime, a β,γ-unsaturated ketone oxime, has given two lactams, 4a,4a-dimethyl-3-aza-A-homocholest-5-en-4-one and 4a,4a-dimethyl-4-aza-A-homocholest-5-en-3-one resulting from photo-Beckmann rearrangement. 4,4,6-Trimethylcholest-5-en-3-one oxime behaved analogously on photolysis, yielding two lactams but accompanied by 4,6-dimethyl-4-methylene-3,4-s

  4,4-二甲基胆甾醇-5-en-3-one肟（一种β,γ-不饱和酮肟）的光反应产生了两种内酰胺，4a,4a-二甲基-3-氮杂-A-homocholest-5-en- 4-one 和 4a,4a-dimethyl-4-aza-A-homocholest-5-en-3-one 由 photo-Beckmann 重排产生。4,4,6-Trimethylcholest-5-en-3-one 肟在光解时表现类似，产生两种内酰胺，但伴随着 4,6-二甲基-4-亚甲基-3,4-secoccholest-5-ene-3-腈作为次要产品。相比之下，普通贝克曼重排的主要产物是二阶贝克曼重排产生的腈。
• Kocovsky,P.; Cerny,V., Collection of Czechoslovak Chemical Communications, 1978, vol. 43, p. 1933 - 1941
  作者：Kocovsky,P.、Cerny,V.

  DOI：——

  日期：——
• Halogenated Cholesterol Analogues and Methods of Making and Using Same
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20210355154A1

  公开（公告）日：2021-11-18

  Provided herein are halogenated cholesterol analogues, including methods of making and using the same. Also provided are methods of making radiolabeled cholesterol analogues including admixing an epoxide with a fluorine-18 source under conditions to form a radiofluorinated cholesterol analogue.