8-(2-amino-phenylamino)-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one | 1133856-05-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并环庚烷吡啶
• 英文名称: 8-(2-amino-phenylamino)-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
• 英文别名: 13-(2-Aminoanilino)-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-one
• CAS: 1133856-05-9
• 化学式: C₂₀H₁₇N₃O
• 分子量: 315.374
• InChiKey: HIQBDOBLHCARQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  68
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  8-氯-5,6-二氢-11H-苯并[5,6]环庚烷并[1,2-b]吡啶-11-酮 、 邻苯二胺 在 potassium tert-butylate 、 palladium diacetate 、 2-二环己基磷-2,4,6-三异丙基联苯 作用下， 以 甲苯 、 叔丁醇 为溶剂， 以14%的产率得到8-(2-amino-phenylamino)-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-one
  参考文献：
  名称：

  Aza-Analogue Dibenzepinone Scaffolds as p38 Mitogen-Activated Protein Kinase Inhibitors: Design, Synthesis, and Biological Data of Inhibitors with Improved Physicochemical Properties

  摘要：

  We recently described a promising novel class of p38 mitogen activated protein (MAP) kinase inhibitors with dibenzepinone-scaffolds. To optimize their physicochemical properties, characterized by calculated log P values and measured lipophilicity (chromatographic hydrophobicity index = CHI), we synthesized aza-analogue dibenzepinones. Here, we present the synthesis and biological data of compounds with the novel aza-dibenzepinone scaffolds. Although these aza-analogues revealed an improved aqueous solubility, introduction of nitrogen was not effective in the p38 MAPK enzyme assay.

  DOI：

  10.1021/jm801291f