methyl 3-(4-phenoxyphenyl)propanoate | 185051-02-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 3-(4-phenoxyphenyl)propanoate
• 英文别名: 3-(4-Phenoxyphenyl)-propionic acid methyl ester
• CAS: 185051-02-9
• 化学式: C₁₆H₁₆O₃
• 分子量: 256.301
• InChiKey: RPKULGMIPIVNLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 3-(4-phenoxyphenyl)propanoate 在 lithium hydroxide monohydrate 、 水 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 6.0h， 生成 3-(4-苯氧基苯基)丙酸
  参考文献：
  名称：

  BODIPY-Based Fluorescent Probe for Peroxynitrite Detection and Imaging in Living Cells

  摘要：

  A fluorescent probe, HKGreen-2, has been developed based on a specific reaction between ketone and peroxynitrite (ONOO-). This probe is highly sensitive and selective for the detection of peroxynitrite not only in abiotic but also in biological systems. With this probe, we successfully detected peroxynitrite generated in murine macrophage cells activated by phorbol 12-myristate 13-acetate (PMA), interferon-gamma (IFN-gamma), and lipopolysaccharide (LPS). This new probe will be a useful tool for studying the roles of peroxynitrite in biological processes.

  DOI：

  10.1021/ol900279z

文献信息

• PHARMACEUTICALLY ACTIVE COMPOUNDS AS DAG-LIPASE INHIBITORS
  申请人：Universiteit Leiden

  公开号：EP3095787A1

  公开（公告）日：2016-11-23

  The present invention relates to novel compounds which are highly selective inhibitors of diacylglycerol lipase α and β. These compounds are suitable for the treatment or prevention of disorders associated with, accompanied by or caused by increased 2-arachidonoylglycerol levels. Diacylglycerol lipase-α (alternative name: Sn1-specific diacylglycerol hydrolase a; DAGL-α) and -β are enzymes responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. Selective and reversible inhibitors are required to study the function of DAGLs in neuronal cells in an acute and temporal fashion. The inventive ompounds are in particular suitable for the treatment of neurodegenerative diseases, inflammatory diseases, drug abuse and impaired energy balance, such as obesity.

  这项发明涉及一种新型化合物，它们是高选择性的二酰甘油脂酶α和β的抑制剂。这些化合物适用于治疗或预防与增加2-花生四烯酰基甘油水平相关、伴随或由此引起的疾病。二酰甘油脂酶-α（另一名称：Sn1特异性二酰甘油水解酶a；DAGL-α）和-β是负责内源大麻素2-花生四烯酰基甘油的生物合成的酶。需要选择性和可逆的抑制剂来研究神经细胞中DAGLs的功能，以一种急性和暂时的方式。这些创新的化合物特别适用于治疗神经退行性疾病、炎症性疾病、药物滥用和受损的能量平衡，如肥胖症。
• [EN] BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE<br/>[FR] DERIVES DE BENZENE, PYRIDINE, NAPHTALENE OU BENZOPHENONE UTILISES COMME INHIBITEURS DE LA SQUALENE SYNTHETASE ET DE LA PROTEINE FARNESYLTRANSFERASE
  申请人：ABBOTT LABORATORIES

  公开号：WO1996034851A1

  公开（公告）日：1996-11-07

  (EN) The present invention provides a compound of formula (I), (II), (III) or (IV), processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical composition, and methods of using the compounds of the invention.(FR) La présente invention se rapporte à des composés de la formule (I), (II), (III) ou (IV), aux procédés de préparation de ces composés, aux intermédiaires utilisés dans ces procédés, à une composition pharmaceutique et aux procédés d'utilisation de ces composés.

  该发明提供了公式（I），（II），（III）或（IV）的化合物，制备该发明化合物的方法，这些方法中有用的中间体，制药组合物以及使用该发明化合物的方法。
• Compounds for treatment of inflammation, diabetes and related disorders
  申请人：——

  公开号：US20040097593A1

  公开（公告）日：2004-05-20

  Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.

  提供了一系列新型酰基脲、硫脲、氨基甲酸酯、硫代氨基甲酸酯及相关化合物，这些化合物在培养细胞中抑制细胞因子介导的炎症反应、改善动物关节炎模型中的骨破坏以及降低动物2型糖尿病模型中的血糖水平方面具有有效性。这些化合物可用于多种治疗，包括糖尿病、胰岛素抵抗、炎症、炎症性疾病、免疫疾病和癌症的治疗。
• COMPOUNDS FOR TREATMENT OF INFLAMMATION, DIABETES AND RELATED DISORDERS
  申请人：Neogi Partha

  公开号：US20070259961A9

  公开（公告）日：2007-11-08

  Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.

  提供了一系列新型酰基脲、硫脲、氨基甲酸酯、硫代氨基甲酸酯及相关化合物，这些化合物在培养细胞中抑制细胞因子介导的炎症反应、改善关节炎动物模型中的骨破坏和降低2型糖尿病动物模型中的血糖水平方面具有有效性。这些化合物被披露为用于多种治疗，包括糖尿病、胰岛素抵抗、炎症、炎症性疾病、免疫疾病和癌症的治疗。
• EP1625207A4
  申请人：——

  公开号：EP1625207A4

  公开（公告）日：2008-11-12