2,4-Diamino-5-methyl-6-aethyl-pyrimidin | 90000-44-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,4-Diamino-5-methyl-6-aethyl-pyrimidin
• 英文别名: 6-ethyl-5-methyl-pyrimidine-2,4-diamine；6-Ethyl-5-methylpyrimidine-2,4-diamine
• CAS: 90000-44-5
• 化学式: C₇H₁₂N₄
• 分子量: 152.199
• InChiKey: HOOXBAUZAWMUSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] MODULATION OF NEURODEGENERATIVE DISEASES<br/>[FR] MODULATION DE MALADIES NEURODEGENERATIVES
  申请人：ALSGEN LLC

  公开号：WO2006096405A2

  公开（公告）日：2006-09-14

  (EN) Methods and compositions are disclosed for selectively interfering with protein synthesis in a central nervous system, meningial, or muscle cell by administrating a pharmacological agent. In particular, methods and compositions that interfere with SOD-I protein synthesis are disclosed.(FR) L'invention porte sur des compositions et sur des méthodes visant à entraver sélectivement la synthèse des protéines dans le système nerveux central, les méninges ou les cellules des muscles, ce procédé consistant à administrer un agent pharmacologique. L'invention porte notamment sur des compositions et sur des méthodes qui entravent la synthèse de la protéine SOD-1.
• [EN] 2,4-DIAMINO-6-ETHYLPYRIMIDINE DERIVATIVES WITH ANTIMALARIAL ACTIVITIES AGAINST PLASMODIUM FALCIPARUM<br/>[FR] DÉRIVÉS DE 2,4-DIAMINO-6-ÉTHYLPYRIMIDINE À ACTIVITÉS ANTIPALUDIQUES CONTRE PLASMODIUM FALCIPARUM
  申请人：NAT SCIENCE AND TECH DEV AGENCY

  公开号：WO2017052479A1

  公开（公告）日：2017-03-30

  The present invention relates to 2,4-diamino-6-ethylpyrimidine derivatives that are inhibitors of wild type and quadruple mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum. They also show in vitro antimalarial activities against Plasmodium falciparum for both wild type and mutant that are comparable to or better than pyrimethamine. In addition, the compounds of the present invention show a good selectivity to Plasmodium falciparum and exhibit lower cytotoxicity than pyrimethamine.