2-benzyl-3-(difluoromethoxy)cyclopent-2-enone | 1422736-29-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzyl-3-(difluoromethoxy)cyclopent-2-enone
• 英文别名: 2-Benzyl-3-(difluoromethoxy)cyclopent-2-en-1-one；2-benzyl-3-(difluoromethoxy)cyclopent-2-en-1-one
• CAS: 1422736-29-5
• 化学式: C₁₃H₁₂F₂O₂
• 分子量: 238.234
• InChiKey: UTWTWZJTJGFYIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二氟氯乙酸乙酯 、 2-benzyl-1,3-cyclopentanedione 在 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 以86%的产率得到2-benzyl-3-(difluoromethoxy)cyclopent-2-enone
  参考文献：
  名称：

  通过ClCF2CO2Et对1,3-二酮进行O-二氟甲基化合成二氟甲基烯醇醚的新方法。

  摘要：

  已经开发了一种简便，有效的单步骤方案，该方案通过从ClCF2CO2Et原位生成二氟卡宾，通过1,3-二酮的O-二氟甲基化合成二氟甲基烯醇醚衍生物。官能团耐受性，反应的可扩展性和温和的反应条件使其成为合成制药和农用化学工业感兴趣的生物学相关二氟甲基醚的有吸引力的方案。

  DOI：

  10.1039/c5ob00020c

文献信息

• Base-free O-difluoromethylation of 1,3-diones with difluorocarbene
  作者：Can Liu、Xiao-Yun Deng、Xian-Liang Zeng、Gang Zhao、Jin-Hong Lin、Hongqing Wang、Ji-Chang Xiao

  DOI：10.1016/j.jfluchem.2016.10.011

  日期：2016.12

  The base-free O-difluoromethylation of 1,3-diones with difluorocarbene generated from difluoromethylene phosphobetaine (Ph3P+CF2CO2−) is described. The convenient reactions proceeded smoothly to give difluoromethyl enol ethers in moderate to good yields.

  游离碱- O-的二氟亚甲基从生成磷酸酯1,3-二酮与二氟卡宾二氟甲基（PH 3 P + CF 2 CO 2 - ）进行说明。方便的反应顺利进行，以中等至良好的产率得到二氟甲基烯醇醚。
• Selective <i>O</i>-Difluoromethylation of 1,3-Diones by Bromodifluoromethylating Reagents
  作者：Guokai Liu、Xin Wang、Xiu-Hua Xu、Xu Lu、Etsuko Tokunaga、Seiji Tsuzuki、Norio Shibata

  DOI：10.1021/ol4000313

  日期：2013.3.1

  The regioselective Odifluoromethylation of 1,3-diones was achieved via in situ generation of difluorocarbene from bromodifluoromethylating reagents in the presence of an organic base. A wide variety of difluormethyl enol ethers were obtained in good to excellent yields. The reaction mechanism is discussed based on ab initio calculations (kcal/mol).
• Selective O-difluoromethylation of 1,3-diones using S-(difluoromethyl) sulfonium salt
  作者：Guo-Kai Liu、Xin Li、Wen-Bing Qin、Wei-Feng Lin、Li-Ting Lin、Jia-Yi Chen、Jian-Jian Liu

  DOI：10.1016/j.cclet.2019.03.036

  日期：2019.8

  A facile and highly efficient approach for selective O-difluoromethylation of 1,3-diones by recently developed bench-stable S-(difluoromethyl)sulfonium salt was described. And a broad range of difluoromthyl enol ethers were readily accessed in good to excellent yields under mild reaction conditions. Mechanistic studies revealed that the O-difluoromethylation reaction proceeds mainly via a difluorocarbene pathway. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
• A new method for the synthesis of difluoromethyl enol ethers by O-difluoromethylation of 1,3-diones with ClCF₂CO₂Et
  作者：Xiaoxi Lin、Zhiqiang Weng

  DOI：10.1039/c5ob00020c

  日期：——

  single-step protocol for the synthesis of difluoromethyl enol ether derivatives by O-difluoromethylation of 1,3-diones via in situ generation of difluorocarbene from ClCF2CO2Et has been developed. The functional group tolerance, scalability of the reaction, and mild reaction conditions make it an attractive protocol for the synthesis of biologically relevant difluoromethyl ethers of interest to the pharmaceutical

  已经开发了一种简便，有效的单步骤方案，该方案通过从ClCF2CO2Et原位生成二氟卡宾，通过1,3-二酮的O-二氟甲基化合成二氟甲基烯醇醚衍生物。官能团耐受性，反应的可扩展性和温和的反应条件使其成为合成制药和农用化学工业感兴趣的生物学相关二氟甲基醚的有吸引力的方案。