4-chloro-5-methylchromane | 893414-28-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 4-chloro-5-methylchromane
• 英文别名: 4-chloro-5-methyl-3,4-dihydro-2H-chromene
• CAS: 893414-28-3
• 化学式: C₁₀H₁₁ClO
• 分子量: 182.65
• InChiKey: OUVIQEPEBAZCKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-chloro-5-methylchromane 、 8-amino-2,3-dimethyl-imidazo[1,2-a]pyridine-6-carboxylic acid methyl ester 在 potassium carbonate 、 sodium iodide 、 水 作用下， 以 丙酮 为溶剂， 反应 48.0h， 以74%的产率得到methyl 2,3-dimethyl-8-[(5-methyl-3,4-dihydro-2H-chromen-4-yl)amino]imidazo[1,2-a]pyridine-6-carboxylate
  参考文献：
  名称：

  WO2006/64339

  摘要：

  公开号：
• 作为产物：
  描述：

  5-甲基-苯并二氢吡喃-4-醇 在 吡啶 、 氯化亚砜 作用下， 以 乙醚 、 氯仿 为溶剂， 反应 13.0h， 以100%的产率得到4-chloro-5-methylchromane
  参考文献：
  名称：

  Chromane Derivatives

  摘要：

  本发明涉及式（I）的化合物或其药学上可接受的盐，其中：R1、R2、R3、R4、R5、R6、R7、R8A和B分别如本文所述或其药学上可接受的盐，以及含有这种化合物的组合物和治疗方法和使用，包括这种化合物用于治疗由酸泵拮抗活性介导的疾病，例如但不限于胃肠疾病、胃食管疾病、胃食管反流病（GERD）、喉咽反流病、消化性溃疡、胃溃疡、十二指肠溃疡、NSAID引起的溃疡、胃炎、幽门螺杆菌感染、消化不良、功能性消化不良、佐林格-埃利森综合征、非侵蚀性反流病（NERD）、内脏疼痛、癌症、心灼热、恶心、食管炎、吞咽困难、多口水、气道疾病或哮喘。

  公开号：

  US20070219237A1

文献信息

• Chromane Derivatives
  申请人：Matsumoto Yukari

  公开号：US20070219237A1

  公开（公告）日：2007-09-20

  This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 A and B are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method of treatment and the use, comprising such compounds for the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), laryngopharyngeal reflux disease, peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, cancer, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.

  本发明涉及式（I）的化合物或其药学上可接受的盐，其中：R1、R2、R3、R4、R5、R6、R7、R8A和B分别如本文所述或其药学上可接受的盐，以及含有这种化合物的组合物和治疗方法和使用，包括这种化合物用于治疗由酸泵拮抗活性介导的疾病，例如但不限于胃肠疾病、胃食管疾病、胃食管反流病（GERD）、喉咽反流病、消化性溃疡、胃溃疡、十二指肠溃疡、NSAID引起的溃疡、胃炎、幽门螺杆菌感染、消化不良、功能性消化不良、佐林格-埃利森综合征、非侵蚀性反流病（NERD）、内脏疼痛、癌症、心灼热、恶心、食管炎、吞咽困难、多口水、气道疾病或哮喘。
• Chromane Substituted Benzimidazole Derivatives as Acid Pump Antagonists
  申请人：Koike Hiroki

  公开号：US20080214519A1

  公开（公告）日：2008-09-04

  This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: A, B, X, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 , R 7 , R 8 and R 9 are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.

  本发明涉及式(I)的化合物或其药学上可接受的盐，其中：A、B、X、R1、R2、R3、R4、R5和R6、R7、R8和R9分别如本文所述或其药学上可接受的盐，以及包含这种化合物的组合物以及在治疗由酸泵拮抗活性介导的疾病，如但不限于胃肠疾病、胃食管疾病、胃食管反流病（GERD）、消化性溃疡、胃溃疡、十二指肠溃疡、NSAID诱导性溃疡、胃炎、幽门螺杆菌感染、消化不良、功能性消化不良、佐林格-埃里森综合症、非侵蚀性反流性疾病（NERD）、内脏疼痛、心口灼热、恶心、食管炎、吞咽困难、多口水、气道障碍或哮喘等疾病中使用这种化合物的用途。
• Chromane Derivatives Useful As Acid Pump Antagonists
  申请人：Jinno Madoka

  公开号：US20090291977A1

  公开（公告）日：2009-11-26

  This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R′, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 A and B are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method of treatment and the use, comprising such compounds for the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori , dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-crosive reflux disease (NERD), visceral pain, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.

  本发明涉及式（I）的化合物或其药学上可接受的盐，其中：R′、R2、R3、R4、R5、R6、R7、R8A和B分别如本文所述或其药学上可接受的盐，以及含有这种化合物的组合物、治疗方法和使用，包括用于治疗酸泵拮抗活性介导的疾病，如但不限于胃肠疾病、胃食管疾病、胃食管反流病（GERD）、消化性溃疡、胃溃疡、十二指肠溃疡、NSAID所致溃疡、胃炎、幽门螺杆菌感染、消化不良、功能性消化不良、佐林格-埃里森综合征、非腐蚀性反流病（NERD）、内脏疼痛、心口灼热、恶心、食管炎、吞咽困难、多唾液、呼吸道疾病或哮喘。
• Chromane substituted benzimidazole derivatives as acid pump antagonists
  申请人：RaQualia Pharma Inc.

  公开号：US07718809B2

  公开（公告）日：2010-05-18

  This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: A, B, X, R1, R2, R3, R4, R5 and R6, R7, R8 and R9 are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-erosive reflux disease (NERD), visceral pain, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.

  本发明涉及公式(I)的化合物或其药学上可接受的盐，其中：A、B、X、R1、R2、R3、R4、R5和R6、R7、R8和R9各自如本文所述或其药学上可接受的盐，并且包含这种化合物的组合物以及在治疗由酸泵拮抗活性介导的疾病中使用这种化合物，例如但不限于胃肠道疾病、胃食管疾病、胃食管反流病（GERD）、消化性溃疡、胃溃疡、十二指肠溃疡、NSAID诱导性溃疡、胃炎、幽门螺杆菌感染、消化不良、功能性消化不良、佐林格-埃里森综合征、非侵蚀性反流病（NERD）、内脏疼痛、心灼热、恶心、食管炎、吞咽困难、过度流涎、气道疾病或哮喘。
• CHROMANE DERIVATIVES USEFUL AS ACID PUMP ANTAGONISTS
  申请人：Pfizer, Inc.

  公开号：EP1838309B1

  公开（公告）日：2008-08-20