2-acetylsulfanyl-benzoic acid amide | 68463-75-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-acetylsulfanyl-benzoic acid amide
• 英文别名: 2-Acetylmercapto-benzoesaeure-amid；S-(2-carbamoylphenyl) ethanethioate
• CAS: 68463-75-2
• 化学式: C₉H₉NO₂S
• 分子量: 195.242
• InChiKey: TUDIQRXTAPFBLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  85.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-acetylsulfanyl-benzoic acid amide 在 盐酸 、 xylene 作用下， 生成 2-methyl-benzo[e][1,3]thiazin-4-one
  参考文献：
  名称：

  Über Oxoverbindungen der Benzo-thiazin-Reihe

  摘要：

  DOI：

  10.1002/ardp.19532860903
• 作为产物：
  描述：

  乙酰氯 、 2-巯基苯甲酰胺 在 吡啶 作用下， 生成 2-acetylsulfanyl-benzoic acid amide
  参考文献：
  名称：

  Über Oxoverbindungen der Benzo-thiazin-Reihe

  摘要：

  DOI：

  10.1002/ardp.19532860903

文献信息

• [EN] THIOETHER PRODRUG COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS<br/>[FR] COMPOSITIONS DE PROMÉDICAMENT THIOÉTHER UTILISÉES COMME AGENTS ANTI-VIH ET ANTIRÉTROVIRAUX
  申请人：US HEALTH

  公开号：WO2015035003A1

  公开（公告）日：2015-03-12

  Disclosed are inhibitors of retroviral growth of formula (I), that are useful in treatment of retroviral infections such as HIV. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one compound or salt of the invention, a method for inactivating a virus, a method for dissociating a metal ion from a zinc finger-containing protein method, and a method for inhibiting the transmission of a virus, wherein R is hydrogen or a linear or branched alkyl.

  公开了一种式(I)的逆转录病毒生长抑制剂，可用于治疗HIV等逆转录病毒感染。还公开了一种包含药用载体和本发明的至少一种化合物或盐的组合物，一种灭活病毒的方法，一种从含锌指蛋白的方法中解离金属离子的方法，以及一种抑制病毒传播的方法，其中R为氢或线性或支链烷基。
• Process for the preparation of saroglitazar pharmaceutical salts
  申请人：Cadila Healthcare Ltd.

  公开号：US10112898B2

  公开（公告）日：2018-10-30

  The present invention relates to an improved process for the preparation of pyrroles derivatives having hypolipidemic and hypocholesteremic activities. In particular, the invention relates to an improved process for the preparation of 2-ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoate and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also relates to an improved process for the preparation of mesylate compound (A1).

  本发明涉及一种制备具有降血脂和降胆固醇活性的吡咯烷衍生物的改进工艺。特别是，本发明涉及一种制备 2-乙氧基-3-(4-(2-(2-甲基-5-(4-(甲硫基)苯基)-1H-吡咯-1-基)乙氧基)苯基)丙酸酯及其药学上可接受的盐、水合物、溶液、多晶型物或中间体的改进工艺。本发明还涉及一种制备甲磺酸盐化合物（A1）的改进工艺。
• THIOETHER PRODRUG COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS
  申请人：The U.S.A. as represented by the Secretary, Department of Health and Human Services

  公开号：EP2580191A2

  公开（公告）日：2013-04-17
• IMPROVED PROCESS FOR THE PREPARATION OF PYRROLE DERIVATIVES
  申请人：CADILA HEALTHCARE LIMITED

  公开号：US20160194280A1

  公开（公告）日：2016-07-07

  The present invention relates to an improved process for the preparation of pyrroles derivatives having hypolipidemic and hypocholesteremic activities. In particular, the invention relates to an improved process for the preparation of 2-ethoxy-3-(4-(2-(2-methyl-5-(4-(methylthio)phenyl)-1H-pyrrol-1-yl)ethoxy)phenyl)propanoate and its pharmaceutically acceptable salts, hydrates, solvates, polymorphs or intermediates thereof. The invention also relates to an improved process for the preparation of mesylate compound (A1).
• [EN] THIOETHER PRODRUG COMPOSITIONS AS ANTI-HIV AND ANTI-RETROVIRAL AGENTS<br/>[FR] COMPOSITIONS DE PRÉCURSEUR DE THIOÉTHER EN TANT QU'AGENTS ANTI-VIH ET ANTI-RÉTROVIRAUX
  申请人：US HEALTH

  公开号：WO2011156674A2

  公开（公告）日：2011-12-15

  Disclosed are inhibitors of retroviral growth of formula (I), that are useful in treatment of retroviral infections such as HIV. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one compound or salt of the invention, a method for inactivating a virus, a method for dissociating a metal ion from a zinc finger-containing protein, and a method for inhibiting the transmission of a virus.