(3S,6S)-1-biphenyl-4-ylmethyl-6-{[bis-(1-methyl-piperidin-4-ylmethyl)-amino]-methyl}-3-naphthalen-2-ylmethyl-piperazine-2,5-dione | 702690-53-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S,6S)-1-biphenyl-4-ylmethyl-6-{[bis-(1-methyl-piperidin-4-ylmethyl)-amino]-methyl}-3-naphthalen-2-ylmethyl-piperazine-2,5-dione
• 英文别名: (3S,6S)-6-[[bis[(1-methylpiperidin-4-yl)methyl]amino]methyl]-3-(naphthalen-2-ylmethyl)-1-[(4-phenylphenyl)methyl]piperazine-2,5-dione
• CAS: 702690-53-7
• 化学式: C₄₃H₅₃N₅O₂
• 分子量: 671.926
• InChiKey: RUCZSFNUCAZENN-YATWDLPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  50
• 可旋转键数：
  11
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  59.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  、 聚合甲醛 在 三乙酰氧基硼氢化钠 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 以30%的产率得到(3S,6S)-1-biphenyl-4-ylmethyl-6-{[bis-(1-methyl-piperidin-4-ylmethyl)-amino]-methyl}-3-naphthalen-2-ylmethyl-piperazine-2,5-dione
  参考文献：
  名称：

  [EN] 2,5-DIKETOPIPERAZINES FOR THE TREATMENT OF OBESITY
  [FR] COMPOSES DESTINES AU TRAITEMENT DE L'OBESITE

  摘要：

  公开号：

  WO2004048345A3

文献信息

• Compounds and compositions for treating obesity
  申请人：Conde-Frieboes Waldemar Kilian

  公开号：US20070185128A1

  公开（公告）日：2007-08-09

  Described herein are novel and useful compounds of the general formula Compounds of this invention can advantageously exhibit melanocortin receptor agonist activity. New and useful compounds comprising such a chemical structure and methods of modulating melanocortin receptor activity in a subject (and promoting, inducing, and/or enhancing the treatment or prevention of related diseases) by administering such a compound or composition also are described.

  本文描述了一种新颖且有用的化合物，其一般公式为。本发明的化合物可以有利地表现为黑色素皮质素受体激动剂活性。还描述了包含这种化学结构的新型和有用的化合物，以及通过给予这种化合物或组合物来调节受体在受试者中的活性（并促进、诱导和/或增强相关疾病的治疗或预防）的方法。
• 2,5-DIKETOPIPERAZINES FOR THE TREATMENT OF OBESITY
  申请人：NOVO NORDISK A/S

  公开号：EP1572669A2

  公开（公告）日：2005-09-14
• [EN] COMPOUNDS FOR USE IN TREATING OBESITY<br/>[FR] COMPOSES DESTINES AU TRAITEMENT DE L'OBESITE
  申请人：NOVO NORDISK AS

  公开号：WO2004048345A2

  公开（公告）日：2004-06-10

  The present invention relates to novel compounds of the general formula (I) as well as any optical or geometric isomer or tautomer form thereof, or a pharmaceutically acceptable salt thereof, as agonists of melanocortin receptors, such as agonists of the MC4 receptor. The compounds may for instance be used in the treatment of obesity.
• [EN] 2,5-DIKETOPIPERAZINES FOR THE TREATMENT OF OBESITY<br/>[FR] COMPOSES DESTINES AU TRAITEMENT DE L'OBESITE
  申请人：NOVO NORDISK AS

  公开号：WO2004048345A3

  公开（公告）日：2004-07-15