1,3-Dichlormethylhydantoin | 15216-12-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1,3-Dichlormethylhydantoin
• 英文别名: 1.3-Dichlor-5-methyl-hydantoin；1,3-dichloro-5-methylhydantoin；1,3-dichloro-5-methyl-imidazolidine-2,4-dione；1,3-Dichloro-5-methylimidazolidine-2,4-dione
• CAS: 15216-12-3
• 化学式: C₄H₄Cl₂N₂O₂
• 分子量: 182.994
• InChiKey: XKGBJFSOWOKVKH-UHFFFAOYSA-N

物化性质

• 密度：
  1.5936 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-甲基乙内酰脲 在 三氯异氰尿酸 作用下， 以 乙腈 为溶剂， 反应 0.5h， 以90%的产率得到1,3-Dichlormethylhydantoin
  参考文献：
  名称：

  A simple and expedient method for the preparation of N-chlorohydantoins

  摘要：

  A simple and efficient methodology for the preparation of N-chlorinated hydantoins is presented. These versatile chlorenium sources were isolated in high yield after a simple recrystaillization. Among the ten examples are the first chiral N-chlorohydantoins. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.11.091

文献信息

• Synthetic Route to 14-Hydroxyl Opiates Through 1-Halo-Thebaine or Analogs
  申请人：Wang Peter X.

  公开号：US20080207906A1

  公开（公告）日：2008-08-28

  Novel methods of synthesis of known and novel 14-hydroxyl opiates through 1-halothebaine and derivatives are described.

  本文介绍了通过1-卤代蒂巴因及其衍生物合成已知和新型14-羟基鸦片类物质的新方法。
• BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS
  申请人：AMGEN INC.

  公开号：US20160046626A1

  公开（公告）日：2016-02-18

  The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.

  本发明提供了式I的化合物及其药学上可接受的盐，它们是电压门控钠通道的抑制剂，尤其是Nav1.7。这些化合物对于治疗与钠通道活性相关的疾病，如疼痛障碍和瘙痒症，非常有用。同时，还提供了含有本发明化合物的药物组合物。
• [EN] BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS<br/>[FR] COMPOSÉS DE SULFONAMIDES BICYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS DU CANAL SODIQUE
  申请人：AMGEN INC

  公开号：WO2014201206A1

  公开（公告）日：2014-12-18

  The present invention provides compounds of Formula I, and pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav1.7. The compounds are useful for the treatment of diseases associated with the activity of sodium channels such as pain disorders and itch. Also provided are pharmaceutical compositions containing compounds of the present invention.

  本发明提供了I式化合物及其药学上可接受的盐，它们是电压门控钠通道的抑制剂，特别是Nav1.7。这些化合物可用于治疗与钠通道活性有关的疾病，如疼痛障碍和瘙痒。还提供了含有本发明化合物的药物组合物。
• Process for preparing 4-haloazetidin-2-ones
  申请人：ELI LILLY AND COMPANY

  公开号：EP0060120A1

  公开（公告）日：1982-09-15

  A process for preparing 4-haloazetidinones of the formu- which comprises reacting in an inert solvent at a temperature between about -20°C. and about 45°C. a 4-sulfino- azetidinone of the formula with at least one molar equivalent of a positive halogen reagent, where in the above formulas M is hydrogen, sodium or potassium, X is chloro, bromo, or iodo; R is a carboxy-protecting group; and R, is an acylamido or diacylamido group useful as intermediates for the preparation of β-lactam antibiotics.

  一种制备式-4-卤代氮杂环丁酮的工艺 式的 4-氨基磺氮杂环丁酮与至少一种摩尔当量的正卤素试剂反应。 式中 M 为氢、钠或钾，X 为氯、溴或碘；R 为羧基保护基团；R 为酰氨基或二酰基氨基，可用作制备 β-内酰胺类抗生素的中间体。
• A SYNTHETIC ROUTE TO 14-HYDROXYL OPIATES THROUGH 1-HALO-THEBAINE OR ANALOGS
  申请人：MALLINCKRODT, INC.

  公开号：EP1893616B1

  公开（公告）日：2010-12-29