2-[1-{3-(2,4-dimethoxyphenyl)-5-(5-(4-nitrophenyl)furan-2-yl)-4,5-dihydro-1H-pyrazolyl}]-4-(4-nitrophenyl)[1,3]thiazole | 1391114-02-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 2-[1-{3-(2,4-dimethoxyphenyl)-5-(5-(4-nitrophenyl)furan-2-yl)-4,5-dihydro-1H-pyrazolyl}]-4-(4-nitrophenyl)[1,3]thiazole
• 英文别名: 2-[5-(3,4-Dimethoxyphenyl)-3-[5-(4-nitrophenyl)furan-2-yl]-3,4-dihydropyrazol-2-yl]-4-(4-nitrophenyl)-1,3-thiazole；2-[5-(3,4-dimethoxyphenyl)-3-[5-(4-nitrophenyl)furan-2-yl]-3,4-dihydropyrazol-2-yl]-4-(4-nitrophenyl)-1,3-thiazole
• CAS: 1391114-02-5
• 化学式: C₃₀H₂₃N₅O₇S
• 分子量: 597.608
• InChiKey: RDVYYEKPPLLDAE-UHFFFAOYSA-N

物化性质

• 熔点：
  182-184 °C
• 沸点：
  783.2±70.0 °C(predicted)
• 密度：
  1.46±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  43
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  180
• 氢给体数：
  0
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  1-(3,4-Dimethoxyphenyl)-3-[5-(4-nitrophenyl)furan-2-yl]prop-2-en-1-one 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 1.0h， 生成 2-[1-{3-(2,4-dimethoxyphenyl)-5-(5-(4-nitrophenyl)furan-2-yl)-4,5-dihydro-1H-pyrazolyl}]-4-(4-nitrophenyl)[1,3]thiazole
  参考文献：
  名称：

  Synthesis, antimicrobial and antioxidant activities of 2-[1-{3,5-diaryl-4,5-dihydro-1H-pyrazolenyl}]-4-(4-nitrophenyl)-[1,3]-thiazoles

  摘要：

  In this study, various substituted chalcones, prepared by condensing substituted acetophenones with substituted aldehydes/arylfurfurals, were treated with thiosemicarbazide in basic media to produce 1-thiocarbonyl-3,5-disubstituted pyrazolines which on further reaction with substituted phenacyl bromides afforded the title compounds in good yield. Structures of the newly synthesized compounds were assigned on the basis of elemental analyses, IR, H-1 NMR, and mass spectral studies. The newly synthesized compounds were tested for their in vitro antibacterial and antifungal activities against a variety of microorganisms and antioxidant activities by diphenylpicrylhydrazyl radical scavenging assay. Among the derivatives, compounds 3b, 3e, 6a, and 6h were identified as potent antioxidants. Compounds 3d, 3e, and 6a-f have emerged as the most promising antimicrobial agents displaying the maximum activity against all the tested microorganisms.

  DOI：

  10.1007/s00044-012-0154-3

文献信息

• Synthesis, antimicrobial and antioxidant activities of 2-[1-{3,5-diaryl-4,5-dihydro-1H-pyrazolenyl}]-4-(4-nitrophenyl)-[1,3]-thiazoles
  作者：Prajwal Lourdes Lobo、Boja Poojary、Manjunatha Kumsi、Vinaya Chandra、Nalilu Sucheta Kumari、K. R. Chandrashekar

  DOI：10.1007/s00044-012-0154-3

  日期：2013.4

  In this study, various substituted chalcones, prepared by condensing substituted acetophenones with substituted aldehydes/arylfurfurals, were treated with thiosemicarbazide in basic media to produce 1-thiocarbonyl-3,5-disubstituted pyrazolines which on further reaction with substituted phenacyl bromides afforded the title compounds in good yield. Structures of the newly synthesized compounds were assigned on the basis of elemental analyses, IR, H-1 NMR, and mass spectral studies. The newly synthesized compounds were tested for their in vitro antibacterial and antifungal activities against a variety of microorganisms and antioxidant activities by diphenylpicrylhydrazyl radical scavenging assay. Among the derivatives, compounds 3b, 3e, 6a, and 6h were identified as potent antioxidants. Compounds 3d, 3e, and 6a-f have emerged as the most promising antimicrobial agents displaying the maximum activity against all the tested microorganisms.