3-(3-fluoro-4-(methylthio)phenylamino)-2-(3,4,5-trimethoxyphenyl)-1H-imidazo[1,2-b]pyrazole-7-carbonitrile | 1258405-55-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并三嗪类
• 英文名称: 3-(3-fluoro-4-(methylthio)phenylamino)-2-(3,4,5-trimethoxyphenyl)-1H-imidazo[1,2-b]pyrazole-7-carbonitrile
• CAS: 1258405-55-8
• 化学式: C₂₂H₂₀FN₅O₃S
• 分子量: 453.497
• InChiKey: QIVGBDRGTCXOBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.83
• 重原子数：
  32.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  96.6
• 氢给体数：
  2.0
• 氢受体数：
  8.0

文献信息

• SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK)
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：EP2443123B1

  公开（公告）日：2017-04-05
• IMMUNOMODULATORY AGENT AND USES THEREFOR
  申请人：The University of Queensland

  公开号：US20150216955A1

  公开（公告）日：2015-08-06

  Disclosed are immunomodulatory agents that are useful for treating or preventing joint damage. More particularly, immunomodulators are disclosed for use in eliciting an antigen-specific tolerogenic response to an aggrecan polypeptide including citrullinated forms thereof to treat or prevent joint damage, including joint damage in subjects with early RA or incipient RA.
• US8377945B2
  申请人：——

  公开号：US8377945B2

  公开（公告）日：2013-02-19
• [EN] SMALL MOLECULE INHIBITORS OF SPLEEN TYROSINE KINASE (SYK)<br/>[FR] INHIBITEURS À PETITE MOLÉCULE DE LA TYROSINE KINASE DE LA RATE (SYK)
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2010147898A2

  公开（公告）日：2010-12-23

  This disclosure concerns compounds which are useful as inhibitors of spleen tyrosine kinase (Syk) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of Syk. This disclosure also relates to pharmaceutical compositions containing these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.