2-Chloromethyl-1-(2-methoxy-benzyl)-1H-benzoimidazole | 7192-09-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-Chloromethyl-1-(2-methoxy-benzyl)-1H-benzoimidazole
• 英文别名: 2-(Chloromethyl)-1-[(2-methoxyphenyl)methyl]benzimidazole
• CAS: 7192-09-8
• 化学式: C₁₆H₁₅ClN₂O
• 分子量: 286.761
• InChiKey: CBJCXPFOXSADRH-UHFFFAOYSA-N

物化性质

• 熔点：
  108-110 °C
• 沸点：
  466.9±35.0 °C(Predicted)
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Aryl and heteroaryl fused aminoalkyl-imidazole derivatives: selective modulators of bradykinin B2 receptors
  申请人：Neurogen Corporation

  公开号：US20020151550A1

  公开（公告）日：2002-10-17

  Disclosed are compounds of the formula: 1 or the pharmaceutically acceptable non-toxic salts thereof wherein: A, B, C. and D are N or CH; X is a bond or (un)substituted CH 2 ; R 1 is lower alkenyl or (un)substituted lower alkyl; R 3 is lower alkyl; and R 2 , R 4 , R 5 , and R 6 are variables defined herein; which compounds are useful in the diagnosis and treatment of renal diseases, heart failure, hypertension, Meniere's disease, vaginal inflammation and pain, peripheral circulatory disorders, climacteric disturbance, retinochoroidal circulatroy disorders, myocardial ischemia, myocardial infarction, postmyocardial infarction syndrome, angina pectoris, restenosis after percutaneous transluminal coronary angioplasty, hepatitis, liver cirrhosis, pancreatitis, ileus, diabetes, diabetic complications, male infertility or glaucoma, or for the increase of permeability of blood-brain barrier, pain, asthma, and rhinitis.

  公开的是以下化合物的结构式：1或其药学上可接受的非毒性盐，其中：A、B、C和D为N或CH；X为键或（未）取代的CH2；R1为较低的烯基或（未）取代的较低烷基；R3为较低的烷基；R2、R4、R5和R6为本文中定义的变量；这些化合物在肾脏疾病、心力衰竭、高血压、梅尼埃病、阴道炎症和疼痛、周围循环障碍、更年期障碍、视网膜脉络膜循环障碍、心肌缺血、心肌梗死、心肌梗死后综合征、心绞痛、经皮冠状动脉成形术后再狭窄、肝炎、肝硬化、胰腺炎、肠梗阻、糖尿病、糖尿病并发症、男性不育症或青光眼的诊断和治疗中有用，或用于增加血脑屏障的通透性、疼痛、哮喘和鼻炎。
• BENZIMIDAZOLE AND IMIDAZOLOPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE MODULATORS OF BRADYKININ B2 (= BK-2) RECEPTORS
  申请人：NEUROGEN CORPORATION

  公开号：EP1165518A2

  公开（公告）日：2002-01-02
• US6358949B1
  申请人：——

  公开号：US6358949B1

  公开（公告）日：2002-03-19
• US7160879B2
  申请人：——

  公开号：US7160879B2

  公开（公告）日：2007-01-09
• [EN] ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF BRADYKININ B2 RECEPTORS<br/>[FR] DERIVES AMINOALKYLIMIDAZOLE FUSIONNES ARYLE ET HETEROARYLE: MODULATEURS SELECTIFS DE RECEPTEURS DE BRADYKININE B2
  申请人：NEUROGEN CORP

  公开号：WO2000059886A2

  公开（公告）日：2000-10-12

  Disclosed are compounds of formula (I) or pharmaceutically acceptable salts thereof wherein: R1 is not 3-fluorobenzyl and represents (C2-C6) alkenyl, aryl (C1-C6)alkyl or heteroaryl (C1-C6)alkyl, OR7, O(CH2)nC(O)R7, O(CH2)nNR7R8, O(CH2)nCO2R7, NR7COR8, COR7, CONR7R8 or CO2R7; R2 represents hydrogen, hydroxy, halogen, trifluoromethyl, trifluoromethoxy, amino (C1-C6)alkyl, mono- or di(C1-C6)alkylamino (C1-C6), or mono- or di(C1-C6)alkylamino(C1-C6)alkoxy; or OR7, O(CH2)nC(O)R7, O(CH2)nNR7R8, O(CH2)nCO2R7, NR7COR8, COR7, CONR7R8 or CO2R7; R3 represents (C1-C6)alkyl; R4 represents halogen or trifluoromethyl; R5 and R6 represent hydrogen, trifluoromethyl, triluoromethoxy, cyano, (C1-C6)alkyl, halogen, (C1-C6)alkylamino(C1-C6)alkyl, mono or di(C1-C6)alkylamino(C1-C6), or mono- or di(C1-C6)alkylamino(C1-C6)alkoxy; or together form a 5 or 6 membered aromatic ring which is optionally substituted. X represents a bond or CH2 which is optionally mono- or disubstituted with a (C1-C6)alkyl or (C1-C6)alkoxy; and A, B, C and D are the same or different and represent CRp or N with the proviso that not more than two of A,B, C and D represent N; which compounds are selective modulators of Bradykinin B2 receptors.