[4-(2-Formamidoethenyl)phenyl] acetate | 66432-08-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: [4-(2-Formamidoethenyl)phenyl] acetate
• CAS: 66432-08-4
• 化学式: C₁₁H₁₁NO₃
• 分子量: 205.213
• InChiKey: RHBPTRLJPZYOHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [4-(2-Formamidoethenyl)phenyl] acetate 在 二甲基亚砜 作用下， 生成 demethyltuberin
  参考文献：
  名称：

  Antibacterial activity of N-(.beta.-styryl)formamides related to tuberin

  摘要：

  A series of para-substituted N-(beta-styryl)formamides, analogues of tuberin (4a), has been prepared and assayed for antibacterial activity. The methylthio, ethoxy, and methyl analogues 4e, 4j, and 4t were about twice as active as tuberin against Mycobacterium phlei. Although tuberin lacks activity against Staphylococcus aureus, several of the analogues described were found to inhibit this organism. The phenyl group of tuberin is not a prerequisite for activity since analogues based on naphthyl or ferrocenyl groups were also active. A quantitative structure-activity relationship further implied that an aromatic group need not be present, suggesting the synthesis of the cyclohexyl and n-amyl analogues which were found to possess high activity.

  DOI：

  10.1021/jm00204a017
• 作为产物：
  描述：

  反式-4-乙酰氧基肉桂酸 生成 [4-(2-Formamidoethenyl)phenyl] acetate
  参考文献：
  名称：

  Antibacterial activity of N-(.beta.-styryl)formamides related to tuberin

  摘要：

  A series of para-substituted N-(beta-styryl)formamides, analogues of tuberin (4a), has been prepared and assayed for antibacterial activity. The methylthio, ethoxy, and methyl analogues 4e, 4j, and 4t were about twice as active as tuberin against Mycobacterium phlei. Although tuberin lacks activity against Staphylococcus aureus, several of the analogues described were found to inhibit this organism. The phenyl group of tuberin is not a prerequisite for activity since analogues based on naphthyl or ferrocenyl groups were also active. A quantitative structure-activity relationship further implied that an aromatic group need not be present, suggesting the synthesis of the cyclohexyl and n-amyl analogues which were found to possess high activity.

  DOI：

  10.1021/jm00204a017

文献信息

• Improvement in the total synthesis of Erbstatin analogs
  申请人：FARMITALIA CARLO ERBA S.r.l.

  公开号：EP0440887A1

  公开（公告）日：1991-08-14

  The present invention relates to a new process for the preparation of Erbstatin and Erbstatin analogs, which can be represented by the following formula (I) wherein R is hydrogen, a lower alkyl or a lower alkanoyl group; n is an integer of 1 to 3; A is -CH=CH- or -CH₂-CH₂-; R₁ is hydrogen or a lower alkyl group, and R₂ is a hydrogen or halogen atom,

  本发明涉及一种制备厄布司他汀和厄布司他汀类似物的新工艺，其可由下式（I）表示 其中 R 是氢、低级烷基或低级烷酰基； n 是 1 至 3 的整数； A 是-CH=CH-或-CH₂-CH₂-； R₁ 是氢或低级烷基，以及 R₂ 是氢原子或卤素原子、
• US5130472A
  申请人：——

  公开号：US5130472A

  公开（公告）日：1992-07-14