4-巯基-2-甲基吡啶 | 100367-70-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 4-巯基-2-甲基吡啶
• 英文名称: 4-Mercapto-2-methyl-pyridin
• 英文别名: 2-Methylpyridine-4-thiol；2-methyl-1H-pyridine-4-thione
• CAS: 100367-70-2
• 化学式: C₆H₇NS
• 分子量: 125.194
• InChiKey: LFXSILHGWCAMTQ-UHFFFAOYSA-N

物化性质

• 熔点：
  147 °C
• 沸点：
  204.9±20.0 °C(Predicted)
• 密度：
  1.122±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  44.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-巯基-2-甲基吡啶 在 氨 、 水 、 potassium hexacyanoferrate(III) 作用下， 生成 Bis-<2-methyl-pyridyl-(4)>-disulfid
  参考文献：
  名称：

  Profft; Rolle, Wissenschaftliche Zeitschrift der Technischen Hochschule Carl Schorlemmer Leuna-Merseburg, 1959, vol. 2, p. 187,190

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氯-2-甲基吡啶 在 乙醇 、 水 、 potassium hydrosulfide 作用下， 生成 4-巯基-2-甲基吡啶
  参考文献：
  名称：

  Profft; Rolle, Wissenschaftliche Zeitschrift der Technischen Hochschule Carl Schorlemmer Leuna-Merseburg, 1959, vol. 2, p. 187,190

  摘要：

  DOI：

文献信息

• Novel 2-Heteroaryl-Substituted Benzimidazole Derivative
  申请人：Nonoshita Katsumasa

  公开号：US20080070928A1

  公开（公告）日：2008-03-20

  A glucokinase activator is provided; and a remedy and/or a preventive for diabetes, or a remedy and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a remedy and/or a preventive for obesity are provided. A glucokinase activator characterized by containing a 2-heteroaryl-substituted benzimidazole derivative of a general formula (I-0) or its pharmaceutically-acceptable salt: [in the formula, X represents a carbon atom or a nitrogen atom; X 1 , X 2 , X 3 and X 4 each independently represent a carbon atom or a nitrogen atom; the ring A represents a 5- or 6-membered nitrogen-containing aromatic hetero ring of a formula (II): (in the formula, X represents a carbon atom or a nitrogen atom); R 1 represents an aryl, etc.; R 2 represents a hydroxy, etc.; R 3 represents a —C 1-6 alkyl, etc.; R 4 represents a —C 1-6 alkyl, etc.; X 5 represents —O—, etc.; a indicates an integer of 1, 2 or 3; q indicates an integer of from 0 to 2; m indicates an integer of from 0 to 2].

  提供了一种葡萄糖激酶激活剂；提供了糖尿病的治疗和/或预防，或者提供了糖尿病的治疗和/或预防，例如视网膜病变、肾病、神经病、缺血性心脏病、动脉硬化，以及肥胖症的治疗和/或预防。葡萄糖激酶激活剂的特征在于包含通式（I-0）的2-杂环芳基取代苯并咪唑衍生物或其药学上可接受的盐：[在公式中，X表示碳原子或氮原子；X1、X2、X3和X4分别独立地表示碳原子或氮原子；环A表示公式（II）的5-或6-成员含氮芳香杂环：（在公式中，X表示碳原子或氮原子）；R1表示芳基等；R2表示羟基等；R3表示-C1-6烷基等；R4表示-C1-6烷基等；X5表示-O-等；a表示1、2或3的整数；q表示0到2的整数；m表示0到2的整数]。
• HETEROCYCLYC SULFONAMIDES HAVING EDG-1 ANTAGONISTIC ACTIVITY
  申请人：Grewal Gurmit

  公开号：US20100029643A1

  公开（公告）日：2010-02-04

  The invention relates to chemical compounds of formula (I), (Ia) and (Ib) or pharmaceutically acceptable salts thereof, which possess Edg-1 antagonistic activity and are accordingly useful for their anti-cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an anti-cancer effect in a warm-blooded animal, such as man.

  该发明涉及化学式（I），（Ia）和（Ib）或其药学上可接受的盐的化合物，其具有Edg-1拮抗活性，因此在抗癌活性和人或动物体的治疗方法中有用。该发明还涉及制造上述化学化合物的过程，含有它们的制药组合物以及在制造用于在温血动物（如人）中产生抗癌效果的药物的制造中使用它们。
• NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT
  申请人：MOCHIDA PHARMACEUTICAL CO., LTD.

  公开号：EP1048666A1

  公开（公告）日：2000-11-02

  Novel fused tetracyclic heterocyclic compounds having a potent and highly selective effect of inhibiting cyclic GMP phosphodiesterase (cGMP-PDE) and a high safety; a process for producing the same; drugs characterized by containing at least one of these compounds as the active ingredient, in particular, preventives and/or remedies for pulmonary hypertension, ischemic heart diseases, erectile insufficiency, female sexual dysfunction or diseases against which cGMP-PDE inhibitory effects are efficacious and intermediates useful in producing the above compounds.

  新型融合四环杂环化合物，具有抑制环 GMP 磷酸二酯酶（cGMP-PDE）的强效和高选择性作用，且安全性高；其生产工艺；以含有至少一种上述化合物作为活性成分为特征的药物，特别是肺动脉高压、缺血性心脏病、勃起功能障碍、女性性功能障碍或 cGMP-PDE 抑制作用有效的疾病的预防和/或治疗药物，以及用于生产上述化合物的中间体。
• PHOTOELECTRIC CONVERSION ELEMENT, DYE-SENSITIZED SOLAR CELL, METAL COMPLEX DYE, DYE SOLUTION, DYE-ABSORBED ELECTRODE, AND METHOD FOR MANUFACTURING DYE-SENSITIZED SOLAR CELL
  申请人：Fujifilm Corporation

  公开号：EP2933875A1

  公开（公告）日：2015-10-21

  A photoelectric conversion element including an electrically conductive support, a photoconductor layer containing an electrolyte, a charge transfer layer containing an electrolyte, and a counter electrode, wherein the photoconductor layer contains semiconductor fine particles carrying a metal complex dye represented by Formula (I); a metal complex dye, a dye solution, a dye-adsorbed electrode, a dye-sensitized solar cell, and a method for producing dye-sensitized solar cell:         M(LD)(LA)·(CI)     Formula(I) wherein, in the formula, M represents a metal ion; LD represents a tridentate ligand represented by formulas (DL-1) to (DL-4); LA represents a specific tridentate ligand; and CI represents a counter ion to neutralize an electric charge: Y1 and Y2 represent an oxygen atom, a sulfur atom, a substituted or unsubstituted nitrogen atom, or a substituted or unsubstituted phosphorus atom; the rings AD and BD represent a hydrocarbon ring or a hetero ring; L represents a linking group represented by the following formulas (L-1) to (L-4); and Ra and Rb each independently represent a substituent, X represents a nitrogen atom or a carbon atom; the ring CD represents a nitrogen-containing hetero ring; T represents -O-, -S-, -NRL2- or -PRL3-; RL1 to RL3 represent a hydrogen atom or a substituent; and Alk represents an alkylene group.

  一种光电转换元件，包括导电支架、含有电解质的光电导层、含有电解质的电荷转移层和对电极，其中光电导层含有携带由式（I）表示的金属络合染料的半导体微粒；一种金属络合染料、一种染料溶液、一种染料吸附电极、一种染料敏化太阳能电池和一种生产染料敏化太阳能电池的方法： M(LD)(LA)-(CI) 式(I) 式中，M 代表金属离子；LD 代表由式（DL-1）至（DL-4）表示的三叉配体；LA 代表特定的三叉配体；CI 代表用于中和电荷的反离子： Y1 和 Y2 代表氧原子、硫原子、取代或未取代的氮原子或取代或未取代的磷原子；环 AD 和 BD 代表烃环或杂环；L 代表由下列式子（L-1）至（L-4）表示的连接基团；Ra 和 Rb 各自独立地代表取代基、 X 代表氮原子或碳原子；环 CD 代表含氮杂环；T 代表-O-、-S-、-NRL2-或-PRL3-；RL1 至 RL3 代表氢原子或取代基；Alk 代表亚烷基。
• THIENOPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS
  申请人：Hongyun Biotech Co., Ltd.

  公开号：EP3498716A1

  公开（公告）日：2019-06-19

  The present invention relates to thienopyrimidine compound, preparation method thereof, pharmaceutical composition and use thereof, and in particular to a type of compounds having ALK and/or c-Met selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for preventing or treating a disease associated with anaplastic lymphoma kinase in vivo, and in the manufacture of a medicament for preventing or treating a disease associated with angiogenesis or cancer metastasis, in particular in the manufacture of a medicament for preventing or treating tumor growth and metastasis.

  本发明涉及噻吩嘧啶化合物、其制备方法、药物组合物及其用途，特别是涉及一种具有ALK和/或c-Met选择性抑制活性的化合物、其制备方法、包含其的药物组合物、以及这些化合物在制造预防或治疗体内无性淋巴瘤激酶相关疾病的药物中的用途，以及在制造预防或治疗血管生成或癌症转移相关疾病的药物中的用途，特别是在制造预防或治疗肿瘤生长和转移的药物中的用途。