4-巯基-苯磺酰胺 | 64058-62-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-巯基-苯磺酰胺
• 英文名称: 4-mercapto-benzenesulfonic acid amide
• 英文别名: 4-Mercapto-benzolsulfonsaeure-amid；p-mercaptobenzenesulfonamide；Benzenesulfonamide, p-mercapto-；4-sulfanylbenzenesulfonamide
• CAS: 64058-62-4
• 化学式: C₆H₇NO₂S₂
• mdl: MFCD01657906
• 分子量: 189.259
• InChiKey: FBAKLWSUNAWWQT-UHFFFAOYSA-N

物化性质

• 熔点：
  140 °C
• 沸点：
  374.9±44.0 °C(Predicted)
• 密度：
  1.444±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.5
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2935009090

反应信息

• 作为反应物：
  描述：

  8-chloro-5,6,7,8-tetrahydroquinoline hydrochloride 、 4-巯基-苯磺酰胺 、 sodium 生成 4-(5,6,7,8-Tetrahydroquinolin-8-ylsulfanyl)benzenesulfonamide
  参考文献：
  名称：

  KENNEWELL, PETER DAVID;CLEMENTS-JEWERY, STEPHEN;WESTWOOD, ROBERT

  摘要：

  DOI：
• 作为产物：
  描述：

  4,4′-disulfanediyldibenzenesulfonamide 在 溶剂黄146 、 锌 作用下， 生成 4-巯基-苯磺酰胺
  参考文献：
  名称：

  Ajello; Pappalardo, Il Farmaco, scienza e tecnica, 1948, vol. 3, p. 145,150

  摘要：

  DOI：

文献信息

• Toxin-Targeted Design for Anticancer Therapy. I: Synthesis and Biological Evaluation of New Thioimidate Heterobifunctional Reagents
  作者：Laura Delprino、Maria Giacomotti、Franco Dosio、Paola Brusa、Maurizio Ceruti、Giorgio Grosa、Luigi Cattel

  DOI：10.1002/jps.2600820515

  日期：1993.5

  In an effort to obtain a more potent and specific immunotoxin for cancer therapy, we designed a series of heterobifunctional linkers characterized by a thioimidate group linked to a S-acetyl thiol (4, 5) or substituted aryldithio group (6-10). These ligands were synthesized by a Pinner-type process from the corresponding nitrile derivatives obtained by thiol-disulphide exchange reaction, reaction with

  为了获得用于癌症治疗的更有效和更特异性的免疫毒素，我们设计了一系列异双功能接头，其特征是与S-乙酰基硫醇（4，5）或取代的芳基二硫基（6-10）连接的亚氨酸亚氨酸酯基团。这些配体通过Pinner型方法由通过硫醇-二硫化物交换反应，与取代的苯-磺酰氯的反应或其他已知方法获得的相应的腈衍生物合成。为了检查用于免疫缀合物制备的选择试剂，我们研究了中间体腈衍生物和半胱氨酸之间的巯基二硫化物交换动力学。在测试的芳基二硫代衍生物（6-10）中，我们选择了3-（4-羧酰胺基-苯基二硫代）丙硫代亚氨酸乙酯（CDPT，9）进行进一步研究。通过分析接头4、5的掺入速率。和9在模型的免疫球蛋白G蛋白中，我们发现CDPT 9和乙基S-乙酰基3-巯基丙硫代亚氨酸酯盐酸盐（AMPT，5）具有相似的结果，因为这两种试剂均显示出引入的硫醇基团数量与时间等因素之间存在线性相关性以及蛋白质和试剂的浓度。两种乙酰硫基衍生物配体4和5的比较表明，AMPT
• Carbapenem derivatives
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US05707987A1

  公开（公告）日：1998-01-13

  A compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group, R.sup.2 is a hydrogen atom or a negative charge, R.sup.3 is a hydrogen atom or a lower alkyl group, Ar is a phenyl group, a naphthyl group or a group of: ##STR2## (wherein each of A.sub.4 and A.sub.5 is a single bond, --NHSO.sub.2 -- or the like, and Het is a pyrrolinyl group, a 1,4-diazabicyclo\x9b2.2.2!octanyl group or the like which may be substituted with a hydroxyl group, a carbamoyl lower alkyl group or the like) which may be substituted with a lower alkyl group, a lower alkylsulfamoyl group or the like which may be substituted with a hydroxyl group, a di-lower alkylsulfonyl group or the like; a hydroxyl group; a di-lower alkylsulfamoyl group or the like, each of A.sub.1, A.sub.2 and A.sub.3 is a single bond or a lower alkylene group which may be substituted with a lower alkyl group, a lower alkylsulfamoyl group or the like which may be substituted with a hydroxyl group, a di-lower alkylsulfamoyl group or the like; a pyridyl group or a pyridino group; and W is a sulfur atom, a single bond; or a pharmaceutically acceptable salt or ester; a process for its production and an antibacterial agent containing it as an active ingredient.

  化合物的结构式为：##STR1## 其中R.sup.1是氢原子或低碳基，R.sup.2是氢原子或负电荷，R.sup.3是氢原子或低碳基，Ar是苯基、萘基或：##STR2## （其中A.sub.4和A.sub.5是单键、--NHSO.sub.2--或类似物，Het是吡咯烷基、1,4-二氮杂双环\x9b2.2.2!辛基或类似物，可用羟基、氨基甲酰低碳基或类似物取代），可用低碳基、低碳基磺酰胺基或类似物取代，可用双低碳基磺酰基或类似物取代；羟基；双低碳基磺酰胺基或类似物，其中A.sub.1、A.sub.2和A.sub.3是单键或低碳亚基，可用低碳基、低碳基磺酰胺基或类似物取代，可用双低碳基磺酰胺基或类似物取代；吡啶基或吡啶酮基；W是硫原子、单键；或药学上可接受的盐或酯；一种制备它的方法和含有它作为活性成分的抗菌剂。
• LITHOGRAPHIC PRINTING PLATE PRECURSOR AND LITHOGRAPHIC PRINTING PROCESS
  申请人：OOHASHI Hidekazu

  公开号：US20110054212A1

  公开（公告）日：2011-03-03

  A lithographic printing plate precursor, which comprises: a support; an image-recording layer; and a protective layer, in this order, wherein at least one of the image-recording layer and the protective layer comprises a phosphonium salt having a specific structure, and a lithographic printing process, which comprises: exposing a lithographic printing plate precursor; supplying an oil-based ink and a fountain solution comprising a phosphonium salt having a specific structure to the exposed lithographic printing plate precursor on a printing machine to remove an unexposed area of an image-recording layer; and conducting printing.

  一种光刻印刷版前体，包括：支撑体；图像记录层；以及保护层，依次排列，其中图像记录层和保护层中至少有一层包含具有特定结构的磷酸铵盐；以及一种光刻印刷工艺，包括：曝光光刻印刷版前体；在印刷机上向曝光的光刻印刷版前体提供具有特定结构的磷酸铵盐的油墨和喷泉溶液，以去除图像记录层中未曝光区域；进行印刷。
• CARBAPENEM DERIVATIVE
  申请人：BANYU PHARMACEUTICAL CO., LTD.

  公开号：EP0747381A1

  公开（公告）日：1996-12-11

  A compound of the formula: wherein R1 is a hydrogen atom or a lower alkyl group, R2 is a hydrogen atom or a negative charge, R3 is a hydrogen atom or a lower alkyl group, Ar is a phenyl group, a naphthyl group or a group of: (wherein each of A4 and A5 is a single bond, -NHSO2- or the like, and Het is a pyrrolinyl group, a 1,4-diazabicyclo[2.2.2]octanyl group or the like which may be substituted with a hydroxyl group, a carbamoyl lower alkyl group or the like) which may be substituted with a lower alkyl group, a lower alkylsulfamoyl group or the like which may be substituted with a hydroxyl group, a di-lower alkylsulfonyl group or the like; a hydroxyl group; a di-lower alkylsulfamoyl group or the like, each of A1, A2 and A3 is a single bond or a lower alkylene group which may be substituted with a lower alkyl group, a lower alkylsulfamoyl group or the like which may be substituted with a hydroxyl group, a di-lower alkylsulfamoyl group or the like; a pyridyl group or a pyridinio group or the like which may be substituted with a lower alkyl group, a carbamoyl lower alkyl group or the like, and W is a sulfur atom, a single bond or the like; or a pharmaceutically acceptable salt or ester thereof, a process for its production and an antibacterial agent containing it as an active ingredient.

  式的化合物： 其中 R1 是氢原子或低级烷基，R2 是氢原子或负电荷，R3 是氢原子或低级烷基，Ar 是苯基、萘基或以下基团： (其中 A4 和 A5 各为单键、-NHSO2- 或类似物，Het 为吡咯烷基、1,4-二氮杂双环[2.2.2]辛烷基或类似物，可被羟基、氨基甲酰基低级烷基或类似物取代），可被羟基、二低级烷基磺酰基或类似物取代；羟基；二低级烷基磺酰胺基或类似基团，A1、A2 和 A3 各为单键或可被低级烷基、低级烷基磺酰胺基或类似基团取代的低级亚烷基，可被羟基、二低级烷基磺酰胺基或类似基团取代；可被低级烷基、氨基甲酰基低级烷基或类似基团取代的吡啶基或吡啶硫基，且 W 为硫原子、单键或类似键；或其药学上可接受的盐或酯、其生产工艺以及含有其作为活性成分的抗菌剂。
• Lithographic printing plate precursor and lithographic printing process
  申请人：Fuji Photo Film Co., Ltd.

  公开号：EP1754597A2

  公开（公告）日：2007-02-21

  A lithographic printing plate precursor, which comprises: a support; an image-recording layer; and a protective layer, in this order, wherein at least one of the image-recording layer and the protective layer comprises a phosphonium salt having a specific structure, and a lithographic printing process, which comprises: exposing a lithographic printing plate precursor; supplying an oil-based ink and a fountain solution comprising a phosphonium salt having a specific structure to the exposed lithographic printing plate precursor on a printing machine to remove an unexposed area of an image-recording layer; and conducting printing.

  一种平版印刷板前体，它依次包括：支撑物；图像记录层；和保护层，其中图像记录层和保护层中的至少一个包括具有特定结构的膦盐，以及一种平版印刷工艺，它包括：曝光平版印刷板前体；在印刷机上向曝光的平版印刷板前体提供油基油墨和包含具有特定结构的鏻盐的润版液，以去除图像记录层的未曝光区域；以及进行印刷。